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HOMEOSTASIS
Definition: i.e. a state of keeping the internal environment constant within physiological limits. What is the internal environment? - 60% of body is made of body fluids Internal environment is the;
CAPILLARY EXCHANGE
Homeostasis occurs at capillary level. Capillaries are the smallest blood vessel ~ one cell thick Substances (e.g. nutrients, O2,CO2 and cellular wastes) move down their concentration gradient across capillary.
There are variations of stress from mild stress to extreme stress. Examples of mild stress - thirst and hunger Examples of extreme tress - poisoning, severe infection
For mild stress, cells respond quickly to restore imbalance For extreme stress, cells may restore incompletely the imbalance and can result in chronic illness or even death. The body has many homeostatic devices to oppose the stimuli of stress and restore internal environment
ALLOSTASIS
A PROCESS WHERE THE HOMEOSTASIS IS CHANGED & SET UP INTO THE NEW VALUE LEVEL.
HOMEOSTASIS
HOMEOSTASIS HOMEOSTASIS
REGULATION OF HOMEOSTASIS
The Nervous system and Endocrine system work together or independently to regulate homeostasis 1) NERVOUS SYSTEM - uses nerve impulses to respond to stresses in the body - response is rapid compare to endocrinal system E.g. Active muscle contraction produces CO2 and O2 in blood. Nerve cells detects changes in blood gases sends impulses to brain brain send impulses to heart to heart rate brain also sends impulses to respiratory centre in brain to breathing rate blood gases are quickly restored back to normal.
REGULATION OF HOMEOSTASIS
2) ENDOCRINAL SYSTEM Uses hormones to responds to stresses and to maintain homeostasis Response is slower than nervous system and also is more fine tuning. E.g. Active muscle contraction produces CO2 and O2 in blood CO2 causes the release of epinephrine into blood epinephrine causes in heart rate delivery to and removal of CO2 in lungs .
2) POSITIVE FEEDBACK LOOP - the response enhances the original stimulus - we see in conditions that does not require fine-tuning - usually switched off by mechanisms outside the system - can be destructive and result in various disorder but some are normal and beneficial. Example: i) Blood clotting. The original signal is amplified until blood clot forms and bleeding is under control. Then other substances help turn off the clotting response. ii) At birth. Positive feedback loop results in strengthening of labor contractions until the baby is finally delivered. iii) Immune response. The positive feedback loop causes the body to amplify the signal and response to contain and quickly remove the pathogen (disease causing agent) from the body.
Anti-platelets
V.Constrictor Br.constrictor Heat-loss Antioxidant Anti body Anti-aging