Escolar Documentos
Profissional Documentos
Cultura Documentos
Orthopedic Bone
screws/fixation replacements
Heart
valves
Metals Synthetic Ceramics
BIOMATERIALS
Semiconductor
Implantable
Materials Biosensors
Microelectrodes
APPL ICAT IONS
•Bio-sugery(Implantation)
•Tissue Engineering
•Bio-aesthetics
•Drug delivery
•Bio-mechanics
•Immunology
•Skin grafting
Why Bio-materials?
• Bio-compatible
• Bio-resorbable
• Bio-degradable
• Bio-inert (donot provoke harmful immune
response)
• Bio-active (in replacing tissues and cells)
• Similar chemical structures
• Less Fatigue Fever
Bioco mp ati bili ty i s primar ily a s ur face
phe no meno n …
Bioengineers
Material Scientists
Immunologists
Chemists
Biologists
Surgeons
...
So me C ommo nl y Used B iomat er ials
Material Applications
Silicone rubber Catheters, tubing
Dacron Vascular grafts
Cellulose Dialysis membranes
Poly(methyl methacrylate) Intraocular lenses, bone cement
Polyurethanes Catheters, pacemaker leads
Hydogels Opthalmological devices, Drug Delivery
Stainless steel Orthopedic devices, stents
Titanium Orthopedic and dental devices
Alumina Orthopedic and dental devices
Hydroxyapatite Orthopedic and dental devices
Collagen (reprocessed) Opthalmologic applications, wound
dressings
FIRST GENERATION
• “ad hoc” implants
• specified by physicians using common and borrowed
materials
• most successes were accidental rather than by design
EXAMPLES:
EX AM PLE :
• titanium alloy dental and orthopaedic implants
• cobalt-chromium-molybdinum orthopaedic implants
• UHMW polyethylene bearing surfaces for total joint
replacements
• heart valves and pacemakers
Artificial Hip Joints
THIR D GEN ERATI ON
EXA MPLE:
•tissue engineered implants designed to regrow rather than
replace tissues
•Integra LifeSciences artificial skin
•Genzyme cartilage cell procedure
•some resorbable bone repair cements
•genetically engineered “biological” components (Genetics
Institute and Creative Biomolecules BMPs)
Substitute Heart Valves
Evolution of Biomaterials
STRUCTURE
SOFT TISSUE
REPLACEMENT
FUNCTIONAL TISSUE
ENGINEERING
CONSTRUCTS
Growth with Nerve Cells
2 - Body Nerve
3 - Nerve Damage
4 - Severed Nerve
5 - Mesh in
Place
6 - Mesh in Place
Cut
7 - Nerve Growth 1
8 - Nerve Growth
2
9 - Nerve Growth
3
10 - Nerve Growth 4
Biomaterials - An Emerging
Industry
• Next generation of medical implants and
therapeutic modalities
• Interface of biotechnology and traditional
engineering
• Significant industrial growth in the next 15
years -- potential of a multi-billion dollar
industry
What are some of the
Challenges?
• To more closely replicate complex tissue
architecture and arrangement in vitro
• To better understand extracellular and
intracellular modulators of cell function
• To develop novel materials and processing
techniques that are compatible with biological
interfaces
• To find better strategies for immune
acceptance