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between these two e'tremities (!enoty$e di##erence $robably written in the e&olutionary model)
FetoPlacental Imbalance
Fetus res$onse
de$endin! on the de!ree o# F-P Imbalance, the mother*s reaction mode and #etus characteristics (!enoty$e)
le$tin
Placenta (ischemic)+
- antian!io!enic #actors
(sFlt-4 and s-En!, amon! others)
%aternal sym$toms
a ran!e o# $ossibilities between the two e'tremes o# maternal res$onsi&eness+ From absence o# sym$toms to se&ere EPH, HE33P etc
Feto-Placental Imbalance
55 (le$tin)
Fetal res$onse+
DE%2ND - adenosine
Fetal needs
%aternal sym$toms+ H;P (hi!h blood $resure), oedema, renal ($rotein-uria etc),
neurolo!ic (coma, sei.ure etc), haematolo!ic (anemia, trombocito$enia etc), li&er (cytolisis etc), &ascular etc 2ssociation o# sym$toms are <nown as syndromes+ $re-eclam$sia, eclam$sia, HE33P etc
,i!nals
Fetus to %other+ adenosine, 5 Fetus to Placenta+ le$tin, 5 Placenta to Fetus+ hy$o'ia, malnutrition, 5
Fields o# action
Research - Dia!nosis (maternal biolo!ical chan!es)+ P2PP 2, P3GF, sF3T-4, adenosine etc - %other !enoty$e+ di##erent sym$toms ? di##erent $ro!nosis (,NPs,5) - Fetus #eatures+ #etal si!nal to $lacenta and mother (le$tin,5)