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Ivermectin
A04 , ,
Transmission of scabies
Mite Sarcoptes scabiei, skin to skin contact Typical vs atypical/crusted/keratotic 2-6 weeks before symptoms are apparent During the incubation period the newly infested healthcare worker could be a source of transmission
Thinking Process
Inadequate treatment of scabies increase transmission of scabies throughout hospitals
Permethrin vs Ivermectin
PICO
Patient
Intervention Comparison
Outcome
Permethrin acts by disrupting the sodium channel current Topical application ensures maximum concentration of the drug in the skin Infrequently used because of its high cost
Ivermectin bind selectively to GABA gated chloride ion channels, which occur in nerve and muscle cells not be effective against the younger stages inside the egg because the nervous system has not yet developed Additional doses needed
Single application of permethrin was superior to a single oral dose of ivermectin by 2 weeks (P < .001).
Permethrin 5% cream (level of evidence 1b, grade of recommendation A) Malathion 0.5% aqueous lotion (level of evidence 4, grade of recommendation C) These should be applied to the whole body from the neck downwards, and washed off after 12 hours, usually overnight. Itch may persist for several weeks. Application of crotamiton cream may give symptomatic relief. Antihistamines may also be helpful in relieving itch. Potentially contaminated clothes and bedding should be washed at high temperature (>50C) if possible. Mites separated from the human host die after 72 hours.
Oral ivermectin in a dose of 200 mcg/kg in the treatment of Norwegian scabies. Ivermectin is not licensed for this purpose in the UK There have been concerns about toxicity