Plasma Proteins

Dr. Niranjan Murthy H L

Asst Prof of Physiology
SSMC, Tumkur
• Albumin
• Globulin- α₁, α₂, β₁, β₂, γ
• Fibrinogen

Origin:
Liver- Albumin & Fibrinogen
Plasma cells, lymphocytes, tissue
macrophages- Globulin
S. Albumin: 3.5-5g/dL
S. Globulin: 2-3g/dL
S. Fibrinogen: 0.3g/dL
 Other proteins
• Antithrombin-III
• Haptoglobulin
• Transferrin
• Angiotensinogen
• Apolipoprotein B
• Clotting factors
• Antithrombin C
 Separation Techniques

1. Salt precipitation
2. Electrophoresis
3. Cohn’s fractionation
4. Ultracentrifugation
5. Gel filtration
ELECTROPHORESIS
 Whipple’s Experiment
• Relation of diet to plasma
• Plasmapheresis

3 types of cellular proteins:

5 Fixed or Indispensible cell proteins
6 Dispensable reserve proteins
7 Labile reserve proteins
 Functions of plasma
proteins
1. Coagulation of Blood
2. Maintain Colloid osmotic pressure
3. Acid-Base balance
4. Immunity
5. Transport functions
6. Maintenance of viscosity of blood
7. Reservoir function
Variations in plasma protein
levels
Reduced albumin:
2 Infancy
3 Pregnancy
4 Hepatitis
5 Cirrhosis
6 Nephrosis
7 burns
Increased globulin:
2 Cirrhosis of liver
3 Tuberculosis
4 Lymphatic leukemia
Decreased Fibrinogen:
6 Congenital
7 DIC
Increased Fibrinogen:
9 Pregnancy
10 malaria