Escolar Documentos
Profissional Documentos
Cultura Documentos
Male Infertility
Peter Conway
April 2005
Male Infertility
Infertility/subfertility
= inability of a couple
to conceive after 1 year of unprotected
intercourse
30 - 40% of couples have a major
identifiable male factor involved
Roughly – ⅓ have male factors
predominating, ⅓ female factors
predominating and ⅓ no cause is found in
either partner
Declining Sperm Counts?
Carlsen, E.; Givercman, A.; Shakkeback, N.E. Evidence
for decreasing quality of semen during past 50 years
British Medical Journal 1992 305:609-13
analysed sperm count data from many studies
concluded there had been a dramatic decline in
sperm counts over 50 yrs
suggested a link with oestrogen-like compounds
such as the pesticides
dichlorodiphenyltrichloroethane (DDT) and 1,2-
dibromo-3-chloropropane (DBCP),
endosulphane
and other pollutants like polychlorinated
biphenyls (PCBs) and dioxins
Safe SH. Endocrine disruptors and human health - is there a
problem? An update.
Environ Health Perspect. 2000 Jun;108(6):487-93.
Results of recent studies show that there are large
demographic variations in sperm counts within countries
or regions, and analyses of North American data show
that sperm counts have not decreased over the last 60
years.
In Scandinavia, the difference between high (Denmark)
and low (Finland) incidence areas are not well
understood and are unlikely to be correlated with
differences in exposure to synthetic industrial chemicals.
Results from studies on organochlorine contaminants
(DDE/PCB) show that levels were not significantly
different in breast cancer patients versus controls. Thus,
many of the male and female reproductive tract
problems linked to the endocrine-disruptor hypothesis
have not increased and are not correlated with synthetic
industrial contaminants.
Wong, W.Y.; Zielhuis, G.A.; Thomas, C.M.; Merkus, H.M.;
Steegers-Theunissen, R.P.
New evidence of the influence of exogenous and endogenous
factors on sperm count in man
Eur J Obstet Gynecol Reprod Biol. 2003 Sep 10;110(1):49-54
Case-control study among 92 fertile and 73 sub
fertile Caucasian males
Serological tests:
LH & FSH
Testosterone
Testicular biopsy
Antisperm antibody
test
Semen analysis
Semen Analysis
Volume – 0.7-6.5ml
Sperm count – 20-150 million/ml
Morphology – at least 40% of
spermatozoa should be normal
Motility – at least 20% of spermatozoa
should show progressive motility within 4
hours of collection
Varicocele
Present in up to 40%
of male fertility
“Varicose vein of the
spermatic cord”
Examine scrotum for
obvious vascular
congestion
•Mobile phones –
precautionary principle
Laptop – not on the lap!
Don’t wrap food in it!
Eat organic
Mineral / filtered water
Non-toxic cleaning/ grooming
Exercise & weight loss
Meditation / relaxation
Lifestyle precautions
Korean ginseng
Adrenal Support
Borago officinalis
Glycyrrhiza glabra
Astragalus
membranaceus
Rehmannia glutinosa
Milk vetch
Nervous Trophorestoratives
Avena sativa
Hypericum
perforatum
Scutellaria lateriflora
Valeriana officinalis
Reproductive Tonics
Serenoa serrulata
Turnera diffusa
Ptychopetalum
olacoides
Detox/ Liver Herbs
Taraxacum officinale
Silybum marianum
Arctium lappa
Apium graveolens
Galium aparine
Viola odorata
Schisandra chinensis
Immune modulators/ enhancers
Echinacea spp.
Tabebuia spp.
Uncaria tomentosa
E
Pelvic Decongestants
Phytolacca decandra
Calendula officinalis
Zanthoxylum clava-
herculis
Anemone pulsatilla
Varicocele Treatment
Aesculus hippocastanum
Calendula officinalis
Zingiber officinalis
Achillea millefolium
Ginkgo biloba
Crataegus spp.
Solidago virgaurea
Zanthoxylum clava-
herculis
Contraindicated herbs?
oral Andrographis leaf powder
caused cessation of
spermatogenesis in male rats
very high oral doses of
andrographolide caused lack of
fertility
but oral Andrographis dried herb
5:1 ethanol extract showed no
adverse effects on male fertility
indices
Mills, S.; Bone, K. 2005 The Essential
Guide to Herbal Safety Elsevier:
Churchill Livingstone