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Definition of terms
Angina Pectoris is the principal symptoms of patient with ischemic heart disease. Manifested by sudden, severe, pressing substernal pain that often radiates to the left shoulder and along the flexor surface of the left arm. Usually precipitated by exercise, excitement or a heavy meal.
Types of Angina
Typical Angina ( Classical Angina ) pain is commonly induced by exercise, excitement or a heavy meal secondary to advanced atherosclerosis of the coronary vessels associated with ST-segment depression on ECG
Variant Angina ( Prinzmetal Angina) pain is induced while at rest associated with ST-segment elevation on ECG secondary to vasospasm of the coronary vessels Unstable angina may involve coronary spasm and may also have the component of atherosclerosis the duration of manifestation is longer than the first two and has the manifestation of Myocardial infarction
Determinants of Vascular Tone Relaxation of vascular smooth muscle by: 1. Increase cGMP 2. Decrease intracellular calcium 3. Increase cAMP 4. Stabilizing or preventing depolarization of the vascular smooth muscle cell membrane
Treatment Plan:
A. decrease the risk factor like atherosclerosis, hypertension, smoking B. increase oxygen supply C. decrease oxygen demand
ANTIANGINAL DRUGS
I. AGENTS WHICH O2 DEMAND & O2 SUPPLY A. NITRATES B. CALCIUM CHANNEL BLOCKERS II. AGENTS WHICH O2 DEMAND C. BETA BLOCKERS
Nitrates
Coronary artery dilatation Decrease coronary bed resistance
(Relieved coronary vasospasm)
Nitrates
Reduction on peripheral resistance
(Secondary to dilatation of aorta)
Decrease workload
Decrease oxygen consumption
Nitrates
Reduced venous return
(Due to dilatation of the veins)
Decrease left ventricular volume Decrease preload Decrease workload Decrease oxygen consumption
Effects
1.
2.
3.
Coronary artery dilatation Reduction of peripheral arterial resistance decrease after load Reduce venous return decrease preload
ROUTES OF ADMINISTRATION
1. Sublingual route rational and effective for the treatment of acute attacks of angina pectoris. Half-life depend only on the rate at which they are delivered to the liver. 2. Oral route to provide convenient and prolonged prophylaxis against attacks of angina 3. Intravenous Route useful in the treatment of coronary vasospasm and acute ischemic syndrome. 4. Topical route used to provide gradual absorption of the drug for prolonged prophylactic purpose.
Drug
Short acting Nitroglycerin Isosorbide dinitrate Amyl nitrite Long acting Nitroglycerin sustained action Nitroglycerin 2% ointment Niroglycerin slow released
Route of administration
sublingual sublingual inhalation oral topical Buccal mucosa
Duration of action
10 - 30 min 10 60 min 3 5 min 6 8 hrs 3 6 hrs 3 6 hrs
transdermal sublingual
oral oral
Isosorbide mononitrate
20 mg per 12 hrs
oral
6 10 hrs
Adverse Effects
1. 2. 3. 4.
Throbbing headache Flushing of the face Dizziness especially at the beginning of treatment Postural Hypotension due to pooling of blood in the dependent portion of the body
Contraindication
1.
2. 3.
Renal ischemia Acute myocardial infarction Patients receiving other antihypertensive agent
B-Blockers
Hemodynamics Effects 1. Decrease heart rate 2. Reduced blood pressure and cardiac contractility without appreciable decrease in cardiac output
B-Blockers
Decrease heart rate & Contractility
Increase duration of diastole Decrease workload
Contraindication
1. 2. 3.
Ca - Channel Blockers
Effects
Coronary artery dilatation 2. Reduction on peripheral arterial resistance decrease after load
1.
Ca Channel Blockers
Coronary artery dilatation Decrease coronary bed resistance
(Relieved coronary vasospasm)
Ca channel Blockers
Reduction on peripheral resistance (Secondary to dilatation of aorta) Decrease blood pressure Decrease after load
Decrease workload
Decrease oxygen consumption
Unwanted effect Nausea and vomiting Dizzyness Flushing of the face Tachycardia due to hypotension
Contraindications Cardiogenic shock Recent myocardial infarction Heart failure Atrio-ventricular block
2.
3.
4.
Type of Angina
STABLE
Other Names
Classic Exertional Fixed Atherosclerotic
Description
Obstruction coronary artery
Drug Therapy
Nitrates CCB B-blockers
VARIANT
UNSTABLE