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Pharmacogenetics?
- Every year in the USA alone 2 million
people experience adverse drug
effects and more than a 100,000 die
from those reactions.
₋ Pharmacogenetic research is
playing a major role in dosing
of Warfarin (an anticoagulant)
Pharmacogenetics vs
Bioethics
Main ethical concerns are
combination of the following:
- Unequal distribution of
benefits/resources
- Invasion of medical privacy
- Discrimination due to the
involvementtof genetic tests
- Research/business conflict-of-
interest
Major Drugs Ineffective
For Many
Joe Hong
Tanvir Kahlon
Shereen Bart
Linnéa Kadfors
Traci Vogler
Jennifer Duncan
David Beshai
References
• Bioethics. (n.d.) In The Free Dictionary. Retrieved from http://www.thefreedictionary.com
• Barash, C.I. (2001). Ethical issues in pharmacogenetics. American Institute of Biological Sciences. Retrieved from
http://www.actionbioscience.org/genomic/barash.html
• Genomics.energy.gov, Genome programs of the U.S Department of Energy Office of Science, Human Genome Project Information.
(2008, September, 19). Pharmacogenomics. Retrived from
http://www.ornl.gov/sci/techresources/Human_Genome/medicine/pharma.shtml
• Gettig, E. (2009). Personalized Medicine. Retrieved from http://mostgene.org/2009_conference/personalized_meds_Gettig.pdf
• Human Genome Project. (2008). Ethical, Legal, and Social Issues. Retrieved from
http://www.ornl.gov/sci/techresources/Human_Genome/elsi/elsi.shtml
• Klug S. William & Cummings R. Michael & Spencer A. Charlotte. Essential of genetics 6th edition. Retrieved from page. 437.
• Lazarou, J., Pomeranz, B. H., Corey, P. N., (1998). Incidence of Adverse Drug Reactions in Hospitalized Patients. JAMA. 279. 1200-5
• Murray, M. F. (2009). Will Plavix be the pharmacogenetics exemplar?. Retrieved from
http://www.entrepreneur.com/tradejournals/article/202479739.html
• National Institute for Health and Clinical Excellence. (2009). Retrieved from http://www.nice.org.uk/
• Stellenbosch University, Department of Biochemistry. (n.d). Ac Swart group (Image of cytochrome P450 oxidase). Retrieved from
http://www0.sun.ac.za/biochem/Imagine/Media/Pictures/220px-CytP450Oxidase-1OG2.png
• University of Liverpool. (n.d). Pharmacogenetics (Image of DNA and pills). Retrieved from
http://liv.ac.uk/pharmacogenetics/dna_and_pills.jpg