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in Pharmaceutical Market. It is dedicated to provide better quality of life to every person and cost effective treatment by focusing on the growing need of pharmaceutical market. Business Evolution: The basis of UniMark business evolution is marketing all over Pakistan With life saving drugs in Cardiovascular Market
Anti-diabetic market
Gynecology
M.TARIQ KHAN
(Product Manager)
Introduction
Humans and other vertebrates have a closed
circulatory system:
This means that circulating blood is pumped through
a system of vessels
This system consists of the heart (pump), series of
The Heart
The Blood The Blood Vessels
The Heart
Located near the center of your chest Hollow structure Composed almost entirely of muscle About the size of your clenched fist
Four chambers
Two atria
Upper chambers Left and right Separated by interatrial septum
Two ventricles
27-8
Heart coverings
Pericardium
Covers the heart and large blood vessels attached to the heart
Visceral pericardium
Parietal pericardium
Tricuspid valve prevents blood from flowing back into the right atrium when the right ventricle contracts Bicuspid valve prevents blood from flowing back into the left atrium when the left ventricle contracts Pulmonary valve prevents blood from flowing back into the right ventricle Aortic valve prevents blood from flowing back into the left ventricle
Right Ventricle
Pulmonary Valve
Body
Lungs
Left Ventricle
Bicuspid Valve
Left Atrium
One heartbeat = one cardiac cycle Atria contract and relax Ventricles contract and relax Right atrium contracts Left atrium contracts Tricuspid valve opens Bicuspid valve opens Blood fills right ventricle Blood fills left ventricle
Right ventricle contracts Tricuspid valve closes Pulmonary semilunar Left ventricle contracts Bicuspid valve closes Aortic semilunar valve
Cardiac Cycle
Influenced by
Exercise
Parasympathetic nerves Sympathetic nerves
Calcium ions
Blood Pressure
Blood pressure is the force or pressure that the blood
exerts on the walls of the blood vessels BP = CO x TPR CO= SV x HR BP = Blood Pressure CO = Cardiac Output TPR = Total Peripheral Resistance SV = Stroke Volume HR = Heart rate
Blood Pressure
Force blood exerts on the inner walls of blood vessels Highest in arteries Lowest in veins Systolic pressure (Normal 120mmHg) Ventricles contract Blood pressure is at its greatest in the arteries
Diastolic pressure (Normal 80mmHg) Ventricles relax Blood pressure in arteries is at its lowest Reported as the systolic number over the diastolic number (120/80mmHg)
PRIMARY HYPERTENSION
It is also called Essential Hypertension About 90% persons have primary hypertension, The main reasons are believed to be involves is
Diet Age Obesity Race Heredity Stress Smoking
SECONDARY HYPERTENSION
Secondary hypertension is due to Excessive renin secretion Arteriosclerosis Endocrine Disorders
What is the difference between the systolic pressure and diastolic pressure?
ANSWER: Systolic pressure is the result of the contraction of the ventricles increasing the pressure in the arteries. Diastolic pressure is the result of the relaxation of the ventricles lowering the pressure in the arteries.
fibers
Purkinje fibers node) Lateral walls of ventricles Between atria just above ventricles Ventricles contract Atria contract Sends impulse to the bundle of His
Baroreceptors
Chemoreceptors Higher centres in the brain Long term control
RAAS system
Baroreceptors
Located in walls of aortic arch and left and right
carotid sinus Mechanical stretch receptors Neuronal circuits in brainstem compare actual value of BP provided by the baroreceptors with the set point or optimal value
Chemoreceptor
Nerve ending situated in the carotid and aortic bodies control of respiration Sensitive to changes in the levels of Co2 , O2 and acidity of the blood
RAAS System
The heart is supplied with arterial blood by the right and left coronary arteries, which branch from the aorta immediately distal to the aortic valve The coronary arteries receive about 5% of the blood pumped from the heart, although the heart comprises a small proportion of body weight
Heart Innervation
Heart receives visceral motor
Electrocardiography
Alterations in Electrocardiogram
Blood
A type of connective tissue Average-sized adult Red blood cells has 4 to 6 liters of (erythrocytes) blood White blood cells (leukocytes) Amount depends on: Platelets cell Size of person fragments Amount of adipose tissue Plasma fluid part of blood Concentrations of
Blood Components
Hematocrit The percentage of red blood cells Normal is about 45% White cells and
platelets = 1%
Plasma = 55%
Erythrocytes Transport oxygen throughout the body Small biconcave-shaped cells Hemoglobin is a pigment in RBCs Oxyhemoglobin carries oxygen; bright red Deoxyhemoglobin does not carry oxygen; darker red Carries carbon dioxide, so also called carboxyhemoglobin Anemia low RBC count Erythropoietin regulates production of RBCs
millimeter of blood Leukocytosis Elevated WBC count Usually due to infection Leukopenia Low WBC count Some viral infections and other conditions
Fragments of cells found in the bloodstream Also called thrombocytes Important in the clotting process of blood Normal count 130,000 to 360,000 platelets per cubic millimeter of blood
composed mostly of water Proteins Albumins Smallest plasma proteins Pull water in to help maintain blood pressure Globulins transport lipids and fat-soluble vitamins Fibrinogen needed for blood clotting
Glucose
Nucleotides Lipids from the
digestive tract Gases oxygen, carbon dioxide, and nitrogen Electrolytes Waste products
Coronary Atherosclerosis; narrowing of coronary Artery Disease arteries caused by hardening of the fatty (CAD) plaque deposits within the arteries
Description
High blood pressure; consistent resting blood pressure equal to or greater than 140/90 mm Hg Bone marrow produces a large number of abnormal WBCs
Leukemia
Murmurs
Myocardial Infarction
Inherited form of anemia; defective hemoglobin chain causes, small, pale, and short-lived RBCs Thrombophleb Blood clots and inflammation develops in a itis vein Varicose Veins Twisted, dilated veins
The doctor has told your patient she has anemia. How would you explain this to the her?
ANSWER: Anemia is a condition in which a person does not have enough red blood cells or hemoglobin in the blood to carry an adequate amount of oxygen to body cells.
CARSEL
CARSEL25 Tablets CARSEL 50 Tablets CARSEL 100 Tablets CARSEL PLUS50 Tablets CARSEL PLUS100 Tablets
PRESCRIBING INFORMATION
Carsel has the antihypertensive effect Metoprolol Tartrate is a selective beta-1adrenoreceptor
blocking agent. CARSEL PLUS has combination of Hydrochlorothiazide that has antihypertensive & diuretics action. Carsel 25,50,100 have Metoprolol Tartrate 25mg,50mg and 100 mg respectively. The 50/25 tablets contain 50mg of Metoprolol Tartrate & 25mg of Hydrochlorothiazide USP. The 100/25 tablets contain 100mg of Metoprolol Tartrate & 25mg of Hydrochlorothiazide USP.
That is hypertension preferably 1 to 2 tablets per day in single in high risk patients with renal or divides doses disease, heart failure or diabetes mellitus
Stage III hypertension 1 to 2 tablets per day in single or divides doses
PRESENTATION
Film coated tablet, blister strip 10 tablets,
PRICE CARSEL 25
Retail Price = 60.00Rs Trade Price = 51.00Rs
CARSEL 50
Retail Price = 95.00Rs Trade Price = 80.75Rs CARSEL 100
Retail Price = 150.00Rs Trade Price = 127.50Rs
CARSEL PLUS
CARSEL PLUS 50 Retail Price =90.00Rs Trade Price = 76.50Rs
PRICE COMPARISON
S# Brand Name Company Strength Packin g Price/ Pack Price/ Tab.
CARSEL
UniMark
30s
BETALOOC ZOK
BH
30s
MEPRESSOR
NOVARTIS
100mg 200 mg
30s 30s
187.48 323.00
6.20 10.76
MIODARONE
MIODARONE
Contain Amiodarone hydrochloride,which is a member of
a new class of antiarrhythmic drugs. The antiarrhythmic effect of Amiodarone is due to: A prolongation of the myocardial cell-action potential duration and refractory period
Noncompetitive - and -adrenergic inhibition Class III of antiarrhythmic drugs .
PRESENTATION
Presented in Alu-Alu packing of 30 Tablets
Price
Retail Price = 331.50 Trade Price = 390.00
PRICE COMPARISON
S# Brand Name Company Strength Packin g Price/ Pack Price/ Tab.
MIOARONE
UniMark
200mg
30s
390.00
13.00
CARDARONE
Sanofi aventis
200mg
30s
464.14
15.4
SEDACORONE
BIO PHARMA
200 mg
50s
585.84
12.00
ANGIPRO 75
Aspirin is acetylsalicylic acid and is antithromoltic,
analgesic, antipyretic and anit-inflammatory agent. The enteric coated Angipro 75 is designed to resist disintegration in the stomach, but to dissolve in a better neutral to alkaline environment of the duodenum.
MECHANISM OF ACTION
Aspirin as anti-platelet drug blocks thromboxane A2 sysnthesis
from arachidonic acid in platelets Aspirins mode of action as an anti-inflammatory and antirheumatic agent may be due to inhibition of synthesis and release of prostaglandins.
INDICATIONS
ANGIPRO 75 (enteric coated Aspirin) is indicated for:
Angina Pectoris Myocardial Infarction Myocardial infarction prophylaxis Transient Ischemic Attacks Prophylactic use of ANGIPRO is also recommended to avoid the chances of thrombo embolic disorders ANGIPRO 75 is also indicated in condition requiring chronic or long-term aspirin therapy for pain and inflammation, e.g. rheumatoid arthritis, Juvenile rheumatoid arthritis,
PRICE
M.R.P. Rs.. 30.00Rs TRADE PRICE25.50Rs
PRICE COMPARISON
Brand Name Company Strength Packing Price/ Pack Price/ Tab.
ANGIPRO
UniMark
75 mg
30s
30.00
1.00
LOPRINE
HIGHNOO N
SCOTMAN N PACIFIC PHARMA Atco
75mg
30s
33.00
1.10
APISCOT
75 mg
30s
30.00
1.00
DOLOPRIN
75mg
30s
30.00
1.00
ASCARD
75mg
30s
33.00
1.10
NIGLYS SR
2.6/6.4mg
Glyceryl Trinitrate Sustained release pellets
Mode of action
Glyceryl trinitrate has dilator properties on vascular
smooth muscle in virtually all vascular beds. The beneficial effects in therapeutic doses and the effects seen with overdose are attributable to the physiologic consequences of systemic venous and arteriolar vasodilatation. The cardiac preload, systemic blood pressure and systemic vascular resistance all show a progressive decrease.
smooth muscle, and reduces systolic blood pressure. It is thought that the anti-anginal effect mainly depends on reducing myocardial oxygen demand by means of peripheral vasodilatation , which causes decreased venous return permitting a reduction in left ventricular volume and energy expenditure.
Indications
1-Prophylaxis and treatment of angina 2- Left ventricular failure. 3-Control of hypertension during cardiac surgery. 4-Congestive cardiac failure unresponsive to usual therapy. 5- IHD, CHD
PRESENTATION
Niglys is available in capsules form as 2.6 mg and 6.4 mg sustained release pellets.
Packing
Niglys 2.6mg = 30s capsules Niglys 6.4mg = 30s capsules
PRICE COMPARISON
S# 1 2 3 4 5 6 7 8 9 10 11 12 Brand Name Niglys SR Niglys SR Angiocard SR Angiocard SR Nitromint Nitromint Cardnit Cardnit Sustac Sustac Nitroscot Nitroscot Company UniMark UniMark Highnoon/ /Biogenics Highnoon/ /Biogenics Medipex Medipex Atco Atco Searle Searle Scottman Scottman Strength 2.6 mg 6.4mg 2.5 mg 6.5mg 2.6 mg 6.4mg 2.6 mg 6.4mg 2.6 mg 6.4mg 2.6 mg 6.4mg Packing 30s 30s 30s 30s 60s 30s 30s 30s 30s 30s 30s 30s Price/ Pack 110.00 150.00 119.84 142.59 221.97 168.00 106.00 130.00 157.22 185.80 130.00 160.00 Price/ Tab. 3.60 5.00 3.99 4.75 3.70 5.60 3.50 4.30 5.24 6.19 4.33 5.33
(UNIPLATE)Clopidogrel
It is an oral, thienopyridineclass antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease.
Mode of action
Clopidogrel is a prodrug, the action of which may be
related to an ADP receptor on platelet cell membranes. The drug specifically and irreversibly inhibits the P2Y12 subtype of ADP receptor, which is important in activation of platelets and eventual cross-linking by the protein fibrin.[1] Platelet inhibition can be demonstrated two hours after a single dose of oral clopidogrel, but the onset of action is slow, so that a loading-dose of 300 mg is usually administered.
PRICE(1X10S)
M.R.P.130.00Rs TRADE PRICE110.00Rs
Brand Name
Company
Strength
Packing
Price/ Pack
Price/ Tab.
UNIPLATE
LOWPLAT
UniMark
PHARM EVO CCL
75 mg
75 mg
10s
10s
130.00.00
140.00
13.00
14.00
NO-CLOT
75mg
10s
140.00
14.00
CLOTNILL
BH
75 mg
10s
130.00
13.00
75 mg 75 mg 75mg
Mode of action
KOLMARK is a selective, competitive inhibitor of
HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3- methylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol. KOLMARK lowers plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase and cholesterol synthesis in the liver and by increasing the number of hepatic LDL receptors on the cell surface to enhance uptake and catabolism of LDL; KOLMARK also reduces LDL production and the number of LDL particles
INDICATIONS
Prevention of Cardiovascular Disease in adult patients without clinically evident coronary heart
disease, but with multiple risk factors for coronary heart disease such as age, smoking, hypertension low HDL-C, or a family history of early coronary heart disease, kolmark is indicated to: Reduce the risk of myocardial infarction Reduce the risk of stroke Reduce the risk for revascularization procedures and angina n patients with type 2 diabetes, and without clinically evident coronary heart disease, but with multiple risk factors for coronary heart disease such as retinopathy, albuminuria, smoking, or hypertension, KOLMARK is indicated to: Reduce the risk of myocardial infarction Reduce the risk of stroke
patients with clinically evident coronary heart disease, KOLMARK is indicated to: Reduce the risk of non-fatal myocardial infarction Reduce the risk of fatal and non-fatal stroke Reduce the risk for revascularization procedures Reduce the risk of hospitalization for CHF Reduce the risk of angina Hyperlipidemia a. LDL-C remains 190 mg/dL or b. LDL-C remains 160 mg/dL
PRICE(1X10S)
KOLMARK 10
M.R.P.125.00Rs TRADE PRICE..106.25Rs
KOLMARK 20
M.R.P.180.00 Rs
TRADE PRICE..153.00 Rs
PRICE COMPARISON
Brand Name Company Strength Packing Price/ Pack Price/ Tab.
KOLMARK
FOPSEC
UniMark
MERCK
10 mg 20mg
10mg 20mg 10mg 20mg 10mg 20mg
10s
10s
125.00 180.00
130.00 22.00 130.00 230.00 150.00 250.00
12.50 18.00
13.00 22.00 13.00 23.00 15.00 25.00
LIPIREX
HIGHNOON
10s
LIPIGET
GETZ
10s
MONOSOR 20/40
(Isosorbide-5-mononitrate) Tablets
MODE OF ACTION
It is of Synthetic origin and belongs to Nitrates. It
belongs to EDRF (NO) agonist pharmacological group on the basis of mechanism of action and also classified in Antianginal Agents and V isosorbide-5-mononitrate is organic nitrate esters commonly used in the treatment of angina pectoris, myocardial infarction, congestive heart failure. Organic nitrate esters have a direct relaxant effect on vascular smooth muscles, and the dilation of coronary vessels improves oxygen supply to the myocardium. The dilation of peripheral veins, and in higher doses peripheral arteries, reduces preload and after-load, and thereby lowers myocardial oxygen consumption.
INDICATIONS
Isosorbide 5-Mononitrate is
primarily indicated in conditions like Congestive heart failure, Prevention and treatment of scurvy, Prophylaxis of angina.
PRICE
MONOSOR 20(2x10s)
M.R.P..77.00Rs Trade Price65.45 Rs
MONOSOR 40 (2x10s)
M.R.P123.00Rs Trade Price104.55 Rs
PRICE COMPARISON
Brand Name Company Strength Packing Price/ Pack Price/ Tab.
MONOSOR
UniMark
20mg 40mg
20s
77.00 123.00
3.85 6.15
MONIS
MAPPLE
20mg 40mg
20mg 40mg 20mg 40mg
20s
77.00 123.00
191.90 308.28 72.30 111.24
3.85 6.15
3.85 6.17 3.62 5.60
ELANTON
ATCO
50s
MONOTRATE
PFIZER
20s