Escolar Documentos
Profissional Documentos
Cultura Documentos
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Sedentary Sedentary Exercising Exercising
*P<0.01 vs. sedentary
*P<0.01 vs. sedentary
Can exercise reverse or prevent
aging or obesity effects?
Exercise-induced changes in total
mitochondrial ETC activity
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* Different (P<0.05)
pre-post training;
paired t-test.
Menshikova et al. J. Gerontol Biol Sci. 2006
Goodpaster unpublished
Exercise and calorie restriction-induced weight
loss effects on mitochondria
Correction of Dysregulated
Metabolism in Obesity
Correction of Dysregulated
Metabolism in Obesity
Diet-induced weight loss Exercise
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Change in post-absorptive fatty acid oxidation
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r = 0.62, P<0.01
Goodpaster, Katsiaras and Kelley, Diabetes, 2003.
Variability in Respiratory Quotient
and its Impact on Weight Gain
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Energy Bal
% Body Fat
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high RQ > 0.87
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Family
Acknowledgments
David Kelley, M.D. CTRC and ONRC staffs
Vladimir Ritov, Ph.D. Nichole Helbling, R.N.
Elisa Menshikova, Ph.D.
John Dub, Ph.D. Paul Coen, Ph.D.
Francesca Amati, M.D., Ph.D. Krista Clark
Andrea Rossi, M.D. Maja Stefanovic, M..D.
Fred Toledo, M..D. Steve Anthony, M.S.
Pete Chomentowski, Ph.D. Kazanna Hames, Ph.D.
Crossing Antarctica with Diabetes:
Taking Diet, Exercise and Diabetes
Management to the Extremes
The Expedition
Ambient temperature during the 61-day trek ranged between
27
o
C and 5
o
C, and altitude steadily rose from 824 m to 2,835
m at the South Pole.
Each man pulled
his own provisions
on a 70 kg sledge
an average of 8.9
hrs per day by
skis.
The Antarctic Diet
The diet goal was:
6,514 kcals, 352 gm fat (47.6% kcals from fat)
Energy Expenditure
Energy Intake
T1DM NOND
-5,590 -7,285
4,018 3,821
-1,572 -3,464 Energy
Balance
Kcal/day
Positive energy
balance = weight gain
Negative energy
balance = weight loss