Escolar Documentos
Profissional Documentos
Cultura Documentos
By:
ILMA INAROH AZIZAH
1101094
Background
Mortality and the
costs that are spent
to tackle the obesityrelated illnesses
In Korea, Rubus
Coreanus can also
treat the obesity
((Jeong, MY. 2013).
Synthesizing
medicines, such
as orlistat, etc.
The antiinflammatory
activity depend on the
degree of Rubus
coreanus ripening.
(Yang, HM. 2008)
Using traditional
medicine such as
green tea extract is
better.
Problems
What is the unripe Rubus
coreanus (uRC) activity on
obesity?
How does it compare to the ripe
Rubus coreanus (RC) ?
Purpose
To determine the anti-obesity
effects of the unripe Rubus
coreanus (uRC) and compare it
to the ripe Rubus coreanus (RC)
Literature Studies
Obesity
According to WHO definition, the
Obesity is an overweight condition that is
an abnormal or excessive fat
accumulation that may impair health.
Previous Works
Yang, HM.
2008
Panchal,
SK. 2012
Jeong,
MY. 2013
IN VITRO
3T3-L1 cells
(preadipocyte
cells)
Cell Culture
Differentiated
into adipocyte
cells
Measured Lipid
Accumulation
using Oil Red O
Staining
Added by extract
of uRC and
extract of RC
IN VIVO
Normal
Diet
(ND)
High Fat
Diet
(HFD)
HFD+uRC
50
mg/kg/day
HFD+uRC
100
mg/kg/day
HFD+
Green Tea
Extract
50 mg/kg/day
In Vivo
Took the blood
and serum
samples from the
mice
Measured its
serum lipid
parameter using
LDX system
Conclusion
uRC administration significantly suppressed lipid
accumulation, body weight gain, adipose
tissue weight, and serum levels of TC, TG,
LDL-cholesterol, and glucose in the 3T3-L1
adipocyte of high fat diet-induced obese
mice.