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Michael J. Ross, MD
Sports Medicine Physician, Rothman Institute
Medical Director, The Performance Lab
August 24,
2012
August
25,2012
9/20/06
Floyd Landis
Doping at a glance
Anabolic steroids
Other anabolics
Stimulants
Blood doping
Discuss strategies for obtaining
desired effects without doping
Testosterone
2007 Christian Moreni arrested at
Tour de France
Testosterone
1996 Dean Capobianco, Australian
100m champion, tests positive for
anabolic steroid stanozol
Testosterone
April 2006 Justin
Gatlin Olympic
gold sprinterfacing 8 year ban
August 2007
Chicago Bears
fullback Obafemi
Ayanbadejo-4
game suspension
Testosterone
1998 Dennis Mitchell 400m relay
gold medalist and 4 time US
champion
Testosterone effects
Increases Lean muscle mass
Increases red blood cell volume
Decreases Body Fat
Testosterone side
effects
Acne
Testicular
suppression
Coronary Artery
Disease
Detecting
Testosterone
If the Ratio of
Testosterone:EpiTestosterone is
greater than 1:1, doping is suspected
Cutoff is 4:1
RadioImmunoAssay
Increasing
Testosterone
Testosterone increases in response to:
Intervals
Strength training
Testosterone decreases in response to
Low Intensity Endurance training
(L.I.E.)
Insulin
One of the major hormones for
controlling blood sugar
building
Br. J. Sports Med., Aug 2003; 37: 356
- 357.
What it does
Insulin is anabolic at large doses.
Imports amino acids into cells to
Side Effects
Too much can cause low blood
Adiposity
What else to do
Glycogen depletion
Replace calories as high glycemic
carbohydrate
Growth Hormone
Anabolic hormone
Secreted in pulses, the largest pulse
happens in the first 1 hour of sleep
GH Effects
Increases recovery (acute)
Increased amino acid uptake into muscle
Increased glycogen through glucose
uptake
GH deficiency
Pituitary disorder
GH a potential treatment for:
frailty
osteoporosis
morbid obesity
cardiac failure
What it does
Side Effects
Cancer
Bony Changes
Jaw and Forehead
Long bones if still growing
Coronary artery disease
Cardiomyopathy
1992
2005
What else to do
Restful sleep
Avoid pre-bedtime snacks containing
fat or carbohydrate
Arginine as secretogogue
Glucocorticoids
Catabolic hormone
Release glucose and fat
Stress steroids
What it does
Side Effects
Muscle breakdown
Central obesity
Moon facies
Osteopenia
Adrenal suppression
What else to do
Caffeine for fatty acid release
Maximize glycogen
supercompensation
Stimulants
Increase alertness and (perceived)
energy
VO2max= HR x SV x (A-V)02
Ephedra: What it
does
Increases time to exhaustion
Increases cardiac output
Increases liver and muscle glycogen
release
Bronchial dilatation
Appetite suppressant
Side Effects
Pre-disposition for heat illness
Appetite suppressant
Insomnia (affects GH)
Tachycardia, arrhythmias and heart
disease
What else to do
Caffeine 4-5mg/kg +
pseudoephedrine 1mg/kg
Blood
Muscles perform best when they can
use oxygen and glucose to make
energy.
VO2= HR x SV x (A-V)02
Operation Puerto
Spanish police raid a lab/office of
Spanish soccer
Tennis
Cycling
aerobic/endurance potential
Alexi Grewal
First gold
medal in
road cycling
since 1912
Alexi had
just
finished a 2
week
suspension
for
Erythropoetin
12-15% increase in power
Decreased lactate accumulation
2002 Mar;86(5):442-9
7% increase in VO2max
rEPO v Aranesp
CERA
Take it out, train, put it back
EPO Dosing
WADA spent millions of dollars over
years
What else to do
Altitude training
Altitude tents
Hypoxic training