Escolar Documentos
Profissional Documentos
Cultura Documentos
From Food to
Fuel
1
The Gastrointestinal Tract
• Organization
– Mouth anus
– Accessory organs
• Salivary glands, liver, pancreas, gallbladder
• Functions
– Ingestion
– Transport
– Secretion
– Digestion
– Absorption
– Elimination
2
Objectives
4
Photosynthesis: Sun’s energy becomes part of glucose molecule
energy
Carbon dioxide
Water GLUCOSE
Chlorophyll
6
Simple Sugars:Mono and Disaccharides
9
• Disaccharides – two linked
sugar units
– Sucrose: glucose + fructose
• “table sugar”
• Made from sugar cane and sugar beets
– Lactose: glucose + galactose
• “milk sugar”
• Found in milk and dairy products
– Maltose: glucose + glucose
• Found in germinating cereal grains
• Product of starch breakdown
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Complex Carbohydrates
• Chains of more than two sugar molecules
• Oligosaccharides
– contain 3-10 sugar molecules
• Polysaccharides
– contain 100’s or 1000’s of monosaccharide
units
– starch-digestible
– fiber-indigestible
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Complex Carbohydrates
• Starch
– Long chains of glucose units
• Amylose – straight chains
• Amylopectin – branched chains;
• Resistant starch-not digested
– Found in grains, vegetables, legumes
• Glycogen
– Highly branched chains of glucose units
– Body’s storage form of carbohydrate
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Glycogen
Major storage
carbohydrate in animals G
G G
Long straight glucose G G G
G G
chains (a1-4) G G
G
Branched every 4-8 glc G GG α 1-6 link
residues (a 1-6) GG
α 1-4 link G
More branched than G
starch G
Less osmotic pressure
Easily mobilized
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Complex Carbohydrates
• Dietary Fiber
– Indigestible chains of monosaccharides
• Oligosaccharides: short chains (3-10)
• Non-starch polysaccharides: long chains
– Cellulose, hemicellulose, pectins, gums, mucilages
• Other: Lignins, cutins, waxes
– Found in fruits, vegetables,
grains, legumes
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Fiber
• Oligosaccharides
– dried beans, peas, lentils
• rafinose (gal-glu-fru)
• stachyose (gal-gal-gal-fru)
• metabolized by intestinal bacteria
• gaseous effects
• Cellulose
– makes walls of cells strong and rigid
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• Hemicelluloses
– mixed with cellulose in cell walls
– outer bran layer
• Pectins
– gel forming; in fruit
• Gums and Mucilages
– thick, gel-forming
– used by food industry to thicken, stabilize,
• Lignins
– not a carb; indigestible substances that make up woody
parts of veg; and fruit seeds
18
Type of Fiber Major Food Action in Body
Sources
Soluble Fiber
Gums, pectins, Fruits (apples, citrus), * Delay GI transit.
some hemicell, oats, barley, legumes * Delay glucose
mucilages; absorption. *Lower
blood cholesterol.
Insoluble Fiber
Cellulose, many wheat bran, corn bran * Accelerate GI
hemicelluloses, whole grain breads transit. *Increase
lignins & cereals, vegetables fecal weight.
*Slow starch hydro-
lysis. *Delay
glucose absorption.
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Transit Times
*Assuming 24
hour Transit
Time 20
Carbohydrate Digestion and Absorption
• 1. MOUTH
• Liquid food = escape digestion in mouth
• Solid food = mastication
• 3 sets of glands secretes
– Salivary α amylase (ptyalin) requires cl‾ and ph
6.6 – 6.8
– It hydrolyzes α 1 – 4 linkage at random deep
inside
– Producing smaller molecules of maltose,
glucose, maltotriose.
2 STOMACH NO ACTION 21
Overview of Digestion
• Physical movement
– Peristalsis
– Segmentation
• Chemical breakdown
– Enzymes
– Other secretions
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Small intestine
Pancreatic amylase completes starch
digestion
Also requirs cl‾, hydrolyse 1 – 4 linkage
– Brush border enzymes digest disaccharides
• End products of carbohydrate digestion
– Glucose, fructose, galactose
– Absorbed into bloodstream
• Fibers are not digested, excreted in feces
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Small Intestine
• Pancreatic enzymes
α -amylase
maltotriose maltose
G G G G G G G G + G G
α amylase
amylose
G G G GG G GG
GG GGGG
GG G
amylopectin
α Limit dextrins
Oligosaccharide digestion..cont
G
G G G α Limit dextrins
GG G sucrase
G G
maltase G
G Glucoamylase (maltase)
or G G G
α -dextrinase
GG α -dextrinase
GG G G
G
GG G
G
Overview of Absorption
Types of absorptive
processes
• Passive Diffusion
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Facilitated
Diffusion
29
Active
Transport
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Portal for transport of virtually all nutrients
Water and electrolyte balance
35
Functions of Carbohydrates
– Energy source
• Glucose is the body’s main fuel
• Adequate glucose spares protein
• Adequate glucose prevents ketosis
– Allows for complete fat
breakdown
– Excess glucose is stored as
glycogen
• Stored in liver and muscle
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• Regulating
blood
glucose
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Hypoglycemia
Nutrition and GI Disorders
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Nutrition and GI Disorders
• Constipation
– Hard, dry, infrequent stools
– Reduced by high fiber, fluid intake,
exercise
• Diarrhea
– Loose, watery, frequent stools
– Symptom of diseases/infections
– Can cause dehydration
• Diverticulosis
– Pouches along colon
– High fiber diet reduces formation
40
A diverticulum
bulges
outward through
weak spots in the
colon. Diverticula
can become
infected--
a condition called
diverticulitis
41
Diabetes
• Diabetes Mellitus
– Persistent high blood glucose levels
– Complications of high BG
– Type 1: lack of insulin production
• Treat with insulin
– Type 2: cells are resistant to insulin
• Treat with diet and exercise
• May treat with oral medications
• May treat with insulin
42
Diabetes
Risk factors for type 2 diabetes
•Age
•Ethnicity
•Obesity
•Hx of Gestational DM
•Family history
•Lack of exercise
43
Carbohydrates in Your Diet
• Increasing
complex
carbohydrate
intake
– Grains,
especially
whole grains
– Legumes
– Vegetables
44
• Artificial Sweeteners
– Minimal or zero kcal
– Many times sweeter than sugar
– Non-cariogenic (don’t promote tooth decay)
– Current products --New Products
• Saccharin * Neotame
• Aspartame * D-tagatose
• Acesulfame * Alitame
• Sucralose
• Sugar alcohols
– ~2 kcal/gram
– Non-cariogenic 45
Carbohydrates and Health
• High sugar intake
– Low nutrient content
– Contributes to tooth decay
– If excess kcal, contributes to obesity
• High fiber intake
– Better control of blood glucose
– Possible reduced cancer risk
– Reduced risk of heart disease
– Healthier gastrointestinal functioning
46
Lactose/disaccharide Intolerance
• Lactose in milk and other dairy foods
• Lactase enzyme
• Symptoms
• Diagnosis and treatment (alternative foods)
• Compared to a milk allergy
Variety of GIT diseases can alter disaccharidases. e.g
Malnutrition,drugs.
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• Rate of absorption decreases from above
down ward. In proximal jejunum 3 time
greater than distil ileum.
• Galactose >glucose> fructose> mannose>
xylose> arabinose
• Some disaccharides enters the cells of GIT
by pinocytosis and are hydralysed within the
cells or eliminated by kidneys.
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