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PAULINA LEVARIO
ID: 142842
(adenohipfisis).
Promueve el crecimiento de los tejidos y
huesos.
Hormona del
crecimiento.
QU PASA CUANDO?
Exceso
Gigantismo pituitario
Dficit
HISTORIA
Anlisis y
Cuantificaci
n de rhGH
SDS-PAGE
Desitometra
Dot Blot
Rendimientos de 95-98%
Plegamiento
Western Blot
HPLC
Dicroismo
Circular
HISTORIA
From 1963 to 1985, patients with growth hormone deficiencies in the U.S. were treated with
growth hormone extracted from pituitary glands taken from cadavers, the researchers
explained. (Gever, 2013:web)
Between 1963 and 1985 the NPA supervised almost
all of the GH treatment in the United States. And
during this period about 7700 children in the United
States and 27,000 children worldwide were given GH
extracted from human pituitary glands to treat severe
Growth hormone deficiency (GHD).
Aceleracin en la AHD
Iatrogenic Creutzfeldt-Jakob
Disease
80 cadveres para 1 ao de
tratamiento!
Estimuladores
Hormona liberadoras de la hormona del
crecimiento (GHRH)
Ghrelina
Hipoglucemia
Hormonas sexuales
Estimuladores fisiolgicos (ejercicio)
Inhibidores
Somatostatina
cidos grasos libres
Hiperglucemia
Glucocorticoides
Dihidrotestosterona
crecimiento
Sndrome de Turner
Enfermedades crnicas del rin
Sndrome de Prader-Willi
Short bowel symdrome
Abuso de la GH
Desempeo atltico
REFERENCIAS
http://www.webmd.com/fitness-exercise/human-growth-hormone-hgh
Nuytens, K., Tuand, K., Fu, Q., Stijnen, P., Pruniau, V., Maulemans, S., Vankelecom, H., Creemers, J. (2014) The Dwarf Phenotype in GH240B Mice,
Haploinsufficient for the Autism Candidate Gene Neurobeachin, is caused by Ectopic Expression of Recombinant Human Growth Hormone. Plos ONE,9(10), 110. doi:10.1371/journal.pone.0109598
Cadaver HGH Cleared as Cause of Alzheimer's http://www.medpagetoday.com/Endocrinology/GrowthDisorders/37193
http://es.wikipedia.org/wiki/Hormona_del_crecimiento
http://eds.b.ebscohost.com/ehost/pdfviewer/pdfviewer?sid=efe2524c-2b44-4538-8a57-19496be5eedd%40sessionmgr115&vid=1&hid=117
http://americanhistory.si.edu/blog/2012/10/human-growth-hormone.html
http://eprints.soton.ac.uk/164599/1/mon1442.pdf
http://www.bibliotecacochrane.com/pdf/CD004440.pdf
http://www.cancer.org/cancer/cancercauses/othercarcinogens/athome/recombinant-bovine-growth-hormone
http://www.smbb.com.mx/congresos%20smbb/puertovallarta03/TRABAJOS/AREA_IX/CARTEL/CIX-10.pdf
http://eds.b.ebscohost.com/ehost/pdfviewer/pdfviewer?sid=7b29514d-e51d-46b3-8587-bbf56e0ae64f%40sessionmgr111&vid=1&hid=117
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685787/
http://mcb.berkeley.edu/courses/mcb41/lecture_17.pdf
http://eds.b.ebscohost.com/ehost/pdfviewer/pdfviewer?sid=0e025489-2557-4550-9707-df4c8e19a65d%40sessionmgr115&vid=1&hid=117
http://eds.b.ebscohost.com/ehost/pdfviewer/pdfviewer?sid=efe2524c-2b44-4538-8a57-19496be5eedd%40sessionmgr115&vid=1&hid=117
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183530/