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Outline
Define pediatric heart failure (HF)
Hemodynamic and pathophysiology
Clinical manifestations
Fluid strategy in management of pediatric HF
Introduction
Cardiac failure is a clinical syndrome where the heart is
unable to provide the output required to meet the
metabolic demands of the body.
The causes and mechanisms are significantly different
between adults and children.
In adults, usually failure of the left ventricle, with the
most common causes is coronary artery disease.
In children,
usually due to congenital malformations, such as left
toright shunts.
The function of the right and the left ventricles will
be affected highoutput cardiac failure.
Other significant causes is cardiomyopathy, which lead
to low output cardiac failure.
Hb
Contractility
CaO2
Stroke
Volume
DO2
Cardiac
Output
Blood
Pressure
Afterload
Heart
Rate
Systemic
Vascular
Resistance
Preload
ASD
RA, RV
enlargement
Increased
pulmonary flow
Relative PS
murmur
AVSD
RA, RV, LA, LV
enlargement
Increased
pulmonary flow
Relative PS and
MS murmur
Large VSD
RV, LA, LV
enlargement
Increased
pulmonary flow
Relative PS and
MS murmur
PDA
LA, LV
enlargement
Increased
pulmonary flow
Continuous
murmur due to
flow during
systole and
diastole
Pulmonary
pathophysiology
in cardiac shunts
Pulmonary flow
Hydrostatic pressure
Capillary leak
Pulmonary oedema
External bronchi
compression
Compliance
Resistance
Atelectasis
Air trapping
Local
inflammation
Work of breathing
Pulmonary
vasoconstriction
Oxygen demand
Hypoxia
Structural changes
PHT
Peribronchial
oedema
RV afterload
RV failure
V/Q Mismatch
Management
To balance the lung and systemic circulation.
to limit lung flooding
to limit systemic underperfusion.
The mainstay of cardiac shunt treatment is diuresis.
Once pulmonary over-circulation is recognised
clinically/radiographically, diuretics should be started
Monitor Na +, K +, Mg 2+ and Ca 2+ (myocardial
function is dependent on optimal electrolyte levels)
Spironolactone is often added to counteract K+ losses
Thiazides are used in neonates (less renal Ca 2+ loss)
General care
Optimise the haemoglobin (Hb) to ensure adequate
oxygen-carrying capacity to the peripheral tissues.
Vasodilator
Diuretic
Vasodilator
Inotrope
Other
(5%)
(15%)
Distribution of Fluids
TBW devided into 2 compartments:
1. Intracellular fluid 40%
2. Extracellular fluid 20%
- Interstitial fluid 15%
- Intravascular fluid 5%
ICF
ISF
IVF
Dextrose 5%
RL, NaCl 0.9%
Colloid
-Blood
-Plasma
-Plasma expander
Conclusions
Infants presenting with respiratory distress should be
assessed for CHD as part of the differential diagnosis
The heart and lungs cannot be seen as separate entities
in cardiac shunt lesions
The main medical treatment for large cardiac shunt
lesions is aimed at active pulmonary diuresis
Blood flow should be balanced between the pulmonary
and systemic circulations
Gentle inotropic support should be used when perfusion
is poor
Attention should be given to nutritional support to all
children with cardiac shunts
Thank you