Escolar Documentos
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INTRACELULAR
Dr. Fredy Paredes
Villanueva
CITOCINA
FACTOR DE CRECIMIENTO
CINASA DE LA PI3
RECEPTORES CON
ACTIVIDAD INTRINSECA
TIROSINA CINASA
RECEPTOR SIN
ACTIVIDAD
INTRINSECA TIROSINA
CINASA
RECEPTOR DE 7 TRAMOS
PLC
JAK
VIA DE LA CINASA PI3
Akt
FOSFORILASA DE
LA CINASA MAP
VIA DE LA IP3
LIBERACION DE IP3
AMPc
LIBERACION DE CA 2+
STAT
ACTIVACION DEL FACTOR DE TRANSCRIPCION
2da ruta
3ra ruta
I MENSAJERO
I MENSAJERO
I MENSAJERO
RECEPTOR
RECEPTOR
RECEPTOR
GMPc
DAG - IP3
Ca
Protein Kinasa A
Protein kinasa G
Protein Kinasa C
Efector interno
Efector interno
Efector interno
PROTEINA G
Es un transductor celular
Esta conformada por 3 subunidades:
alfa, beta y gamma
En reposo: GDP unido a la subunidad
alfa
En actividad: GTP desplaza al GDP y
se separa la subunidad alfa de las
subunidades beta y gamma
EFECTORES INTERNOS
Serina-treonina kinasas
Tirosina-kinasas
Kuala
Lumpur,
Malasia
http://www.cellsignal.com/
reference/pathway/MAPKERK
asp
G-protein-coupled receptors
(GPCRs) are activated by a
wide variety of external
stimuli.
Upon
receptor
activation
the
G-protein
exchanges GDP for GTP,
causing the dissociation of
the GTP-bound Galpha and
the Gbetagamma subunits,
triggering diverse signaling
cascades. Receptors coupled
to different heterotrimeric Gprotein subtypes can utilize
different scaffolds to activate
the small G-protein/ MAPK
cascade, employing at least
three different classes of
tyrosine kinases. Src family
kinases
are
recruited
following
activation
of
PI3Kgamma by Gbetagamma
subunits. They are also
recruited
by
receptor
internalization,
crossactivation
of
receptor
tyrosine kinases, or by
signaling through an integrin
scaffold
involving
Pyk2
and/or FAK. GPCRs can also
employ PLCbeta to mediate
activation
of
PKC
and
CaMKII, which can have
either
stimulatory
or
inhibitory consequences for
the
downstream
MAPK
pathway.
AF2
+ ER
Receptor
AF1 dimerization
Coactivator
AF1
Nuclear
localization of
fully active ER
to ERE
AF1 + AF2
ACTIVE
E=Estrogen.
ER=Estrogen receptor.
AF1=Activation function 1.
AF2=Activation function 2.
ERE=Estrogen response element.
RNA POLII=RNA polymerase II.
ERE
Coactivator
RNA
POLII
FULLY
ACTIVATED
TRANSCRIPTION
(tumor cell
division)
GRACIAS !!!!!!!