Escolar Documentos
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Oleh :
Robiokta Alfi Mona, S.Ked
04054821517120
Pembimbing : dr. Henry Sugiharto, SpS
dr. Andika
Introduction
Poliovirus
Enterovirus (RNA)
Three serotypes: P1, P2, P3
Minimal heterotypic immunity between
serotypes
Rapidly inactivated by heat, formaldehyde,
chlorine, ultraviolet light
Poliomyelitis Pathogenesis
Clinical Features
Laboratory Testing
Viral Isolation
Poliovirus may be recovered from the stool
Serology
Two specimens are needed, one early in the
course of the illness and another three weeks
later. A four-fold rise in the titer suggests
poliovirus infection.
Cerebrospinal Fluis (CSF)
In poliovirus infection, the CSF usually contains
an increased number of white blood cells (10200
cells/mm3, primarily lymphocytes) and a mildly
elevated protein (4050 mg/100 mL).
Epidemiology
Reservoir
- human
Transmission
- fecal-oral
- oral-oral possible
Communicability
- most infectious 7-10 days before and after
onset of symptoms
- virus present in stool 3-6 weeks
Poliovirus Vaccine
Poliovirus Vaccine
1955Inactivated vaccine
1961Types 1 and 2 monovalent OPV
1962Type 3 monovalent OPV
1963Trivalent OPV
1987Enhanced-potency IPV (IPV)
Polio Eradication
Last case in United States in 1979
Western Hemisphere certified polio free in
1994
Last isolate of type 2 poliovirus in India in
October 1999
Global eradication goal
Post-polio Syndrome
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