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PERIPROSTHETIC INFECTION
IN THE FUTURE
A REVIEW OF NEW FORMS OF TREATMENT
PROLOGUE
The number of arthroplasties being
undertaken is expected to grow year on
year.
Despite many initiatives to reduce it over
the years, the rate of periprosthetic joint
infection (PJI) remains at 1%-2%.
Most common pathogen: S. Aureus
Adheres to the prosthesis, duplicates,
colonises.
Becomes resistant to antibiotics.
PROLOGUE
Biofilm:
Polypeptides
Polysaccharides
Nucleic acid
EXPANDED SEARCH
Photodynamic therapy
Implant infections
Metal ions
Prosthesis infections
Nanoparticles
Hip infections
Magnetic fields
Knee infections
Electric fields
Shoulder infections
Future
Patient
Modifications
Theatre
Technique
RESULTS
1.
2.
3.
4.
5.
6.
7.
Theatre modifications
Operative modifications
Modification of prostheses
Antibiotic prosthetic coatings
Antibiofilm prosthetic coatings
Intra-operative applied therapies
External antimicrobial therapy
THEATRE MODIFICATIONS
Presence of five people: increase the
bacterial count by 34 times (from skin,
respiratory particles, hair, clothing)
Laminar flow
UV light
Sterilising the operating room between
patients or overnight
OPERATIVE MODIFICATIONS
MODIFICATIONS OF
PROSTHESES
Structure of the prosthesis
Surface
Texture
Hydrophobicity
ANTIBIOTICS PROSTHETIC
COATINGS
Vancomycin
Gentamicin
Ceftriaxone
Kanamycin
Tetracycline
Doxycycline
Levofloxacin
Dispersin B
Targets intercellular adhesion produced
by the biofilm.
EXTERNAL ANTIMICROBIAL
THERAPY
Photodynamic therapy (PDT)
Magnetic and electric fields
Charge nanotubular titanium using a
voltage of 15 to 30 volts decrease
formation of biofilm
Shockwave treatment
EPILOGUE
Bacteria cannot be fully eradicated
from the skin. S. Aureus is a human
commensal, adding the risk of infection
to every incision, despite skin
antisepsis.
The test demonstrate that bacteria can
adhere to the surface of the prosthesis,
but not sufficient to cause infection.
Q&A
Dr. Asep SpBS tampilkan dulu
abstraknya. Yang dibagikan ke peserta
adalah full text, jangan ppt. jika ada
infeksi, bagaimana tata laksananya?
Jika belum ada implan failure, AB dulu.