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Sensory Physiology
Lectures by
Paul Findell
University of Texas, Austin
Table 10-1 (1 of 2)
Table 10-1 (2 of 2)
Sensory Pathways
Somatosensory Receptors
Stimulus
Unmyelinated
axon
Cell body
(a)
Copyright 2009 Pearson Education, Inc.
Figure 10-1a
Somatosensory Receptors
Stimulus
Enclosed nerve
ending
Layers of connective
tissue
Myelinated axon
Cell body
(b)
Copyright 2009 Pearson Education, Inc.
Figure 10-1b
Somatosensory Receptors
Stimulus
Specialized receptor
cell (hair cell)
Synaptic vesicles
Synapse
Myelinated axon
Cell body of
sensory neuron
(c)
Copyright 2009 Pearson Education, Inc.
Figure 10-1c
Sensory Receptors
Table 10-2
Sensory Transduction
Primary sensory
neurons
Secondary
sensory
neuron
Figure 10-2
Two-point
discrimination
varies with the
size of the
secondary
receptive field
(a)
Compass with points
separated by 20 mm
Skin surface
Primary
sensory
neurons
Secondary
sensory
neurons
Figure 10-3a
Two-point
discrimination
varies with the
size of the
secondary
receptive field
(b)
Compass with points
separated by 20 mm
Skin surface
Primary
sensory
neurons
Secondary
sensory
neurons
Figure 10-3b
Integration by CNS
Sensory information
Spinal cord to brain by ascending pathways
Directly to brain stem via cranial nerves
Sensory Pathways
Sensory Pathways
Primary somatic
sensory cortex
Gustatory cortex
Olfactory cortex
Olfactory bulb
Auditory
cortex
Visual
cortex
Eye
Cerebellum
Nose
Thalamus
Sound
Brain
stem
Equilibrium
Tongue
Somatic
senses
Copyright 2009 Pearson Education, Inc.
Sensory Pathways
Primary somatic
sensory cortex
Gustatory cortex
Olfactory cortex
Olfactory bulb
Auditory
cortex
Visual
cortex
Eye
2
Nose
Cerebellum
Thalamus
Sound
Brain
stem
Equilibrium
Tongue
Somatic
senses
Copyright 2009 Pearson Education, Inc.
Sensory Pathways
Primary somatic
sensory cortex
Gustatory cortex
Olfactory cortex
Olfactory bulb
Auditory
cortex
Visual
cortex
Eye
2
Nose
Cerebellum
Thalamus
Sound
Brain
stem
Equilibrium
3
Tongue
Somatic
senses
Copyright 2009 Pearson Education, Inc.
Sensory Pathways
Primary somatic
sensory cortex
Gustatory cortex
Olfactory cortex
Olfactory bulb
Auditory
cortex
Visual
cortex
Eye
2
Nose
Cerebellum
Thalamus
Sound
Brain
stem
Equilibrium
3
Tongue
Somatic
senses
Copyright 2009 Pearson Education, Inc.
Figure 10-4
Indicated by where
Sensory neurons are activated
Neurons terminate in brain
Lateral inhibition
Increases contrast between activated receptive
fields and inactive neighbors
Population coding
Multiple receptors functioning together
Figure 10-5
Primary neuron
response is proportional
to stimulus strength.
Primary
sensory
neurons
Pathway closest to
the stimulus inhibits
neighbors.
Secondary
neurons
Inhibition of lateral
neurons enhances
perception of stimulus.
Tertiary
neurons
A
Copyright 2009 Pearson Education, Inc.
Pin
Stimulus
Stimulus
C
Tonic level
C
Tonic level
Figure 10-6
Properties of Stimulus
Intensity
Coded by number of receptors activated and
frequency of action potentials
Duration
Coded by duration of action potentials
Some receptors can adapt or cease to respond
Properties of Stimulus
Trigger zone
Cell body
Myelinated axon
Axon terminal
Duration
(a) Moderate
stimulus
20
0
-20
-40
Threshold
-60
-80
0
10
10
10
10
10
Time (sec)
Membrane potential (mV)
Amplitude
Stimulus
20
0
-20
-40
-60
-80
0
1
10
Receptor potential
strength and
duration vary with
the stimulus.
0
2
Receptor potential
is integrated at the
trigger zone.
Frequency of action
potentials is proportional
to stimulus intensity.
Duration of a series of
action potentials is
proportional to stimulus
duration.
Neurotransmitter
4 release varies with
the pattern of action
potentials arriving
at the axon terminal.
Figure 10-7
Figure 10-8a
Figure 10-8b
Touch
Proprioception
Temperature
Nociception
Pain
Itch
THALAMUS
MEDULLA
Fine touch,
proprioception,
vibration
Nociception,
temperature,
coarse touch
KEY
Primary sensory neuron
Secondary sensory neuron
Tertiary neuron
SPINAL CORD
THALAMUS
MEDULLA
Fine touch,
proprioception,
vibration
Nociception,
temperature,
coarse touch
KEY
Primary sensory neuron
Secondary sensory neuron
Tertiary neuron
SPINAL CORD
3 Sensory pathways
synapse in the thalamus.
3
THALAMUS
MEDULLA
Fine touch,
proprioception,
vibration
Nociception,
temperature,
coarse touch
KEY
Primary sensory neuron
Secondary sensory neuron
Tertiary neuron
SPINAL CORD
3 Sensory pathways
synapse in the thalamus.
3
THALAMUS
MEDULLA
Fine touch,
proprioception,
vibration
Nociception,
temperature,
coarse touch
KEY
Primary sensory neuron
Secondary sensory neuron
Tertiary neuron
SPINAL CORD
3 Sensory pathways
synapse in the thalamus.
3
THALAMUS
MEDULLA
Fine touch,
proprioception,
vibration
Nociception,
temperature,
coarse touch
KEY
Primary sensory neuron
Secondary sensory neuron
Tertiary neuron
SPINAL CORD
Figure 10-9
Figure 10-10
Meissners corpuscle
responds to flutter and
stroking movements.
Hair
Free nerve
ending
Hair root
Sensory nerves
carry signals to
spinal cord.
Pacinian corpuscle
senses vibration.
Ruffini corpuscle
responds to skin
stretch.
Figure 10-11
Temperature Receptors
Warm receptors
Above body temperature to about 45C
Pain receptors activated above 45C
Nociceptors
Nociceptors Pathways
Table 10-5
Itch
Histamine activates C fibers causing itch
Pain
Subjective perception
Fast pain
Sharp and localizedby A fibers
Slow pain
More diffuseby C fibers
Figure 10-12a
Figure 10-12b
Figure 10-12c
Referred Pain
Skin
(usual stimulus)
Primary sensory
neurons
Kidney
(uncommon stimulus)
(b)
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Secondary
sensory
neuron
Ascending sensory
path to somatosensory
cortex of brain
Figure 10-13b
Pain
Ischemia
Lack of adequate blood flow