Escolar Documentos
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Cultura Documentos
Biologi Molekuler
Riandini Aisyah
2009
History
In
In 1953, DNA
(deoxyribonucleic acid) was
discovered as a double helix
structure by Watson and
Crick using data collected
by Rosalind Franklin.
Code
Properties
Universal
Degenerate
Unambiguous
Contains
Common
Origin of Life
1970 American
microbiologist, Daniel
Nathans, discovers first restriction enzyme
which can cut specifically cut DNA at a
specific recognition site.
Central Dogma
Gene
Genome
Transcription
RNA
Transcriptome
Translation
Protein
Proteome
NUCLEAR GENOME
* 23 pairs of chromosomes 2 X ( 3 X
109 b.p) 2 meters DNA / Cell
* 2 X ( 3 X 1012 ) meters DNA in human
body 8,000 X (earth to moon)
MITOCHONDRIAL GENOME
Human 4 x 109
22 autosom yang berbeda
2 sex kromosom
Masing2 single linier DNA
Nucleotides:
A - T
G - C
Sugar:
De oxy ribose
Ribose
Phosphate
STRUCTURE :
DNA
one protein
DNA
RNA
Protein
(Central Dogma)
RNA -
m RNA
t RNA
r RNA
Fungsi RNA
m RNA
t
r RNA
- protein synthesis
GENOME :
Mus musulus : mammalia
Homo sapiens
3.109 bp DNA
3.5 109 bp
DNA / Genes
* existence
* multicopy
* rearrangement
* mutation
* structural / sequence changes
RNA :
* gene expression
* level of expression
* degradation time
* gene function