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EXTRACTION of ANALGESICS
Objectives
http://www.wonderhowto.com/how-to/video/how-to-do-a-liquid-liquidextraction-in-the-chemistry-lab-259811/view/
Vacuum
Filtration
http://video.google.com/videoplay?docid=4541453194468704643#docid=1104445520143750871
Drying
Organic Solvents
http://www.wonderhowto.com/how-to/video/how-to-dry-an-organic-solution-in-thechemistry-lab-259802/view/
ACTIVE INGREDIENTS
GOODYS POWDERS
O
H
O
H3C
O H
CH3
O
OH
Aspirin
Acetaminophen
2-Acetylsalicylic acid
4-acetamidophenol
MF: C9H8O4
MF: C8H9NO2
mp: 138-140 C
mp 169-172oC
pKa: ~3.5
pKa: ~10
o
500 mg/powder
325 mg/powder
ACIDBASE EXTRACTION
CHEMICAL EQUATIONS
O
O
CH3
CH3
O
C
+
O, Na
O
C
+ Na+ , HCO3- (aq)
O H
H2CO3
Sodium carboxylate
Carboxylic acid
Organic insoluble,
water soluble
Organic soluble,
water insoluble
HCl(aq)
O
CH3
H2O + CO2(g)
O
C
O H
Carboxylic acid
Organic soluble,
water insoluble
O
H
CH3
+ Na+ , HCO3- (aq)
OH
Acetaminophen
Organic soluble,
water insoluble
NO REACTION
Acetaminophen remains
soluble in the organic phase and
insoluble in the aqueous phase
ACIDBASE EXTRACTION
FLOW CHART
2 Goody's Powders
25 mL Ethyl Acetate
25 mL sat. NaHCO3
Separatory
funnel
Organic layer
(acetaminophen)
aqueous layer
(aspirin salt)
Organic layer
(acetaminophen)
1. dry over
MgSO4
2. filter
3. evaporate
Aspirin
Acetaminophen
Always keep
one finger on
the stopper!
OVERVIEW
Perform acid/base
extraction using
separatory funnel.
ACETAMINOPHEN
(O)
ASPIRIN SALT
(A)
OVERVIEW
ACETAMINOPHEN
OVERVIEW
ASPIRIN
Calculate % recovery.
THEORETICAL RECOVERY
Theoretical Recovery:
PERCENT RECOVERY
Table 6.1
Aspirin
Acetaminophen
calculated
calculated
Obtain weight
Obtain weight
this lab!
next lab!
calculated
calculated
Table 6.2
HPLC retention times (min) and area %
Standards
Compound
Rt
(min)
Aspirin
Sample
Rt
area %
(min)
Acetaminophen
Sample
Rt
area %
(min)
Aspirin
Acetaminophen
Samples containing a single compound are considered PURE samples,
while those containing both compounds are considered MIXED (IMPURE)
samples.
Be sure to attach both sample chromatograms to final lab report!
SAFETY CONCERNS
WASTE MANAGEMENT
LABORATORY NOTEBOOK
(Pre-lab)
OBJECTIVE
MW (g/mol)
bp (Co)
mp (Co) d (g/mL)
HAZARDS
XXX
XXX
XXX
XXX
XXX
XXX
XXX
XXX
XXX
REFERENCE TO PROCEDURE
(Must include)
full title
Edition
authors
page numbers where actual procedure can be found
LABORATORY NOTEBOOK
(In-lab)
DATA/CALCULATIONS
EXTRACTION:
EXPERIMENTAL PROCEDURE