TELAAH ARTIKEL

PENELITIAN
DESAIN KOHORT
Pembimbing:
dr. Djap Hadi S.,M.Kes
Disusun oleh:
Sharania Manivannan
11-2014 - 182

TOPIC
Prospective Cohort Study of
Green Tea Consumption and
Colorectal Cancer Risk in
Women

PROBLEM

Tea

and

its

antioxidative,

constituents
anti-

have

inflammatory,

shown
and

anticarcinogenic activities in numerous in vitro

and animal studies.

Organ sites that are accessible directly to orally

administered tea, such as digestive tract, are
thought to represent good targets for potential
chemoprevention by tea because of the high
bioavailability.

AIM
The inverse association with regular
tea drinking was observed for both
colon and rectal cancers.This study
suggests that regular consumption
of green tea may reduce CRC risk in
women

DESIGN
Analitic
Prospective cohort study.

VARIABLE
Depende
nt

Independ
ent

Colorectal
cancer in
women

Green tea
consumpti
on

POPULATION DAN
SAMPLE74,942 women

between 1996
and 2000 from
seven urban
communities of
Shanghai
Women aged
40 to 70
years at
baseline.

CRITERIA
INKLUSIF :
demographic characteristics, lifestyle and dietary habits,
medical

history,

and

family

history

of

cancer.

Anthropometric measurements, including current weight,

height, and circumferences of the waist and hips.
EKSKLUSIF:
history

of

cancer,

diabetes,

or

familial

adenomatous

polyposis, subjects with an extreme total energy intake

(<500 or >3,500 kcal/d, subjects lost to follow-up since
enrollment, or subjects who drank black or oolong tea
regularly and exclusively.

METHODS AND
MATERIALS
Questionaires
The death certificate data, medical charts
from hospitals, endoscopy, radiography
(barium-air double contrast radiography
and computed tomographic scans) or
ultrasound.

CONCEPTUAL
FRAMEWORK
Type and
amount of tea
Age she
started such
habit

Drank tea
regularly (at
least thrice
per week
lasting at
least 6
months)

Tea leaves
consumed
past year

Colorect
al
Cancer
Risk in
Women

Current status
of tea
consumption.

DATA ANALYSIS
STATISTIC ANALITIK- multivariate
The Cox proportional hazards model was
used to compute relative risks (RR) of
developing CRC associated with green tea
consumption and their 95% confidence
intervals (95% CI) after adjusting for
potential confounding variables.

HASIL

RESULT

RESULT

CONCLUSION
In this large population-based prospective
cohort

study,

we

found

that

regular

consumption of green tea was inversely

associated with the risk of CRC, particularly
among women who maintained such habit
over time. The longer the duration of
lifetime tea consumption, the lower was
the risk of CRC.

PROPOSITION
This prospective cohort study among women
in Shanghai provides one of the strongest
pieces of evidence in humans that regular
consumption of green tea may confer a
protection against CRC.
These findings are consistent with data
from in vitro and in vivo experiments,
indicating that tea may serve as an
effective chemopreventive agent

TERIMA KASIH