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m
materials
b. Synthesis protein process
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Protein folding
Delivery to different cell
compartments
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CHARGED POLAR
proteins.
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The folding of a
protein chain is :
constrained by many
different noncovalent
bonds
hydrogen bonds
ionic bonds
van der Waals
attractions
involve atoms in
polypeptide
backbone and in side
chains.
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The one-dimensional
information contained in the
primary amino acid sequence of
cellular proteins is enough to
guide a protein into its threedimensional structure, to
determine
its specificity for interaction with
other molecules
its ability to function as an enzyme
to set its stability and lifetime.
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Antibodies, or immunoglobulins:
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Feedback inhibition:
an enzyme acting early in a reaction pathway
is inhibited by a late product of that pathway.
can work almost instantaneously and is
rapidly reversed when the level of the
product falls.
is negative regulation: it prevents an enzyme
from acting.
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