Escolar Documentos
Profissional Documentos
Cultura Documentos
Dermatology examination
http://abernethydermatology.com/skin-cancer-detection-exams
Diagrammatic cross section of human skin. Accessory organs of the skin include hair, nails,
and cutaneous glands
http://www.nlm.nih.gov/medlineplus/ency/imagepages/8682.htm
http://www.dartmouth.edu/~anatomy/Histo/lab_4/skin/DMS033/popup.html
Integumentary tissues
Which layer(s) of the skin is/are
comprised of epithelial tissue?
Which layer(s) of the skin is/are
comprised largely of connective
tissue?
Hairs
Sweat pores
Dermal papilla
Tactile corpuscle
(touch receptor)
Epidermis
Blood capillaries
Dermis
Hair follicle
Sebaceous gland
Hair receptor
Apocrine sweat gland
Hypodermis
(subcutaneous fat)
Hair bulb
Sensory
nerve fbers
Merocrine sweat
gland
Piloerector muscle
Lamellar (pacinian)
corpuscle (pressure receptor)
Cutaneous blood
vessels
Motor nerve fbers
FIGURE 6.1 Structure of the Skin and Subcutaneous Tissue. The epidermis is peeled up at the
upper left corner to show the dermalepidermal boundary.
Which image - left or right - shows thin skin, and which shows thick skin?
How did you know?
http://www.lab.anhb.uwa.edu.au/mb140/corepages/integumentary/integum.htm
Barrier
Thermoregulation
Sensory reception
Vitamin D synthesis
Nonverbal communication
Lactation
Figure 6.2
(a)
Epidermis
Read The Epidermis (pp. 178-182) and study the following slide to learn about the
epidermis; be able to answer/address the following:
Learn the epidermal layers in thin and thick skin.
Learn these cells types, their structural organization, and their important properties:
Basal cells (stem cells) of the Stratum Basale
Keratinocytes of the Stratum Spinosum, Stratum Granulosum, Stratum Lucidum, and
Stratum Corneum
Know how keratinocytes change in terms of structure and properties as they
progress from being components of the Stratum Granulosum to being
components of the Stratum Corneum.
Learn these cell types, their locations, and their important functions in the epidermis.
Melanocytes, Dendritic Cells, Langerhans Cells
Be able to explain the four structural/functional processes in keratinocytes of the stratum
granulosum that give rise to the epidermal water barrier of the skin
Epidermis
Epidermis
Cell Layers
Cell Types
The dermis
http://antranik.org/integumentary-system-part-1/
The dermis
The dermis
Transdermal Absorption
Drugs most suitable for transdermal transport have high lipid solubility. Why do
you suppose that is?
To be effective, the transdermal drug must reach the dermis - why?
http://ceaccp.oxfordjournals.org/content/7/5/171.full
http://www.walgreens.com/store/c/habitrol-nicotine-transdermal-system%2c-21mg-stop-smoking-aid-step-1/ID=prod6109355-product
The hypodermis
The hypodermis is comprised
partly of areolar connective
tissue, but is mostly comprised
of ________ tissue.
In the hypodermis, fat cells are
organized into lobules, loosely
separated from each other by
intervening connective tissue.
Label a lobule on the histology
slide at right, and intervening
connective tissue.
What are the major functions of
the hypodermis?
http://www.lab.anhb.uwa.edu.au/mb140/corepages/integumentary/integum.htm
Skin color
Melanin, a tyrosine derivative with two
major forms in mammals
Melanin synthesis and distribution
Effects of UV radiation, sunlight, on
melanin synthesis & skin color
Variation in Melanin deposition across
integument
Skin color
Skin color
Abnormal skin colors of diagnostic value include:
Jaundice:
Johnny Winter
1.
2.
3.
4.
5.
- cooling function
- excretory function
-barrier function
- scent function
http://health.howstuffworks.com/skin-care/information/anatomy/how-sweat-works2.htm
Apocrine
sweat gland
Merocrine Gland
Figure 6.11a
Merocrine
sweat gland
Apocrine Gland
Skin Cancer
http://www.biooncology.com/research-education/braf/metastatic-melanoma
http://emedicine.medscape.com/article/2045059-overview
http://treatmentresources.blogspot.com/2011/08/what-causes-skin-cancer-skin-neoplasms.html
Melanoma
MAPK pathway
activation
transcriptional regulation,
proliferation, differentiation,
survival
http://emedicine.medscape.com/article/2045059-overview