Journal Reading

Herpes zoster as a risk factor for stroke

and TIA
A retrospective cohort study in the UK
Presented by : dr. Ratri Wulandari S
Supervisor : dr. Billy Indra Gunawan, SpS

MEDICAL FACULTY OF SRIWIJAYA UNIVERSITY

MOH. HOESIN HOSPITAL PALEMBANG

INTRODUCTION

HERPES
ZOSTER

STROKE,
TIA, MI

introduction

Material and Methods

A retrospective cohort

Setting :

UK population-based matched cohort study

followed for up to 24 years

Data were extracted from patients routinely attending 464 general

practices between 2002 and 2010.

Cox
proportional
hazard
models

adjusted for
vascular risk
factors

the risks of
stroke, TIA,
and MI in
cases and
controls

BMI, smoking, cholesterol,

hypertension, diabetes,
ischemic heart disease, AF,
intermittent arterial
claudication, carotid stenosis,
and valvular heart disease

Selection of participants

Results
Risk factors for vascular
disease were significantly
increased in cases of HZ
compared with controls.

Discussion

suggestio
n

Population studies are

now needed to evaluate
whether immunization
to prevent HZ could
also
reduce
the
incidence of vascular
events including stroke,
TIA, and MI.

Critical Appraisal
No

Question

Answer

Why was study done?

to evaluate herpes zoster as a risk

factor for stroke
and TIA

What is the sample size?

Case 43.418 (men) and 63.183

(women). Control 88.582(men) and
124.620 (women)

Are the instruments of the major variables valid

and reliable?

YES ( THIN)

How were the data analyzed?

SAS versi 9.2

Did people leave the study and, if so, was there

something special about them?

NO

Did the researchers base their work on a

thorough literature review?

YES

Is the study purpose an important clinical issue?

YES

LINKS OF THIN

https://www.ucl.ac.uk/pcph/research-groups-themes/thin-pub/dat
abase

http://www.epic-uk.org/our-data/our-data.shtml

Intinyo ucl ini peringkat 10 besar dunia beb, pasti valid.