DISEO DE INVESTIGACIN

CLNICA: EL QU Y EL CMO
ANATOMA Y FISIOLOGA DE LA
INVESTIGACIN CLNICA
Should people eat more fish?
How often do Americans eat fish?
Does eating more fish lower the
risk of cardiovascular disease?
Is there a risk of mercury toxicity
from increasing fish intake in
older adults?
Do fish oil supplements have the
same effects on cardiovascular
disease as dietary fish?
Which fish oil supplements dont
make your breath smell like fish?
 ANATOMA Y FISIOLOGA DE LA
INVESTIGACIN CLNICA
Diseo
Observacional
Estudios de cohorte
Prospectivos (EC) (FR seguir
outcome)
Retrospectivos (Outcome: FR)
Caso- control
Transversales (estudios prevalencia)
Ensayos clnicos
A doble ciego
ANATOMA Y FISIOLOGA DE LA
INVESTIGACIN CLNICA
Descriptivo
What is the average number of servings of fish per week in the diet of
1 Americans with a history of coronary heart disease (CHD)?

Analtico
Do people with a CHD who eat a lot of fish have a lower risk of
2 recurrent myocardial infarction than people with a history of CHD who
rarely eat fish?

Ensayo clnico
Does treatment with fish oil capsules reduce total mortality in people
3 with CHD?

This is a cross-sectional study of dietary habits in 50- to 69-year-old people with a

history of
CHD, followed by a prospective cohort study of whether fish intake is associated with
ANATOMA Y FISIOLOGA DE LA INVESTIGACIN
CLNICA.- DISEANDO ESTUDIO
What is the prevalence of daily ingestion of fish oil supplements among people with CHD?

Among a sample of patients seen in the investigators clinic who have a previous CHD
diagnosis and respond to a mailed questionnaire, what proportion report taking daily fish
oil supplements?
ANATOMA Y FISIOLOGA DE LA INVESTIGACIN
CLNICA.- ERRORES DISEO E IMPLEMENTACIN
ERRORES EN LA INVESTIGACIN
CMO FUNCIONA?
 PREGUNTA DE
INVESTIGACIN Y
DESARROLLO PLAN
ESTUDIO
GENERALIDADES

Orgenes
Pregunta de investigacin vs
pregunta de inters
Dominio literatura
Estar alertas de lo nuevo
Imaginacin- escepticismo
Escoger un mentor
DESARROLLO DE
PREGUNTA Y PLAN DE
ESTUDIO
Enfoques
Consejera: equipo, expertos en el tema
Proceso iterativo

Preguntas primarias y secundarias

INVESTIGACIN DE TRANSFERENCIA