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Mechanisms of Disease
Regeneration and
Fibrous Repair
Dr Peter Furness
pnf1@le.ac.uk
Department of Pathology
ACUTE INFLAMMATION,
CHRONIC INFLAMMATION,
OR FIBROUS SCARRING?
Acute Chronic
insult insult
Acute
inflammation
Damage Chronic
slight? No inflammation
Yes
Resolution Repair
possible and
SCARRING
REGENERATION AND REPAIR
Regeneration:
replacement of functional, differentiated cells
Repair:
production of a fibrous scar
REGENERATION
Labile cells:
- normal state is active cell division
- usually rapid regeneration
Stable cells:
- not normally dividing at a significant rate
- speed of regeneration variable
Permanent cells:
- unable to divide
- unable to regenerate
Factors controlling regeneration:
Complex and poorly understood.
Growth factors
EGF, PDGF, FGF, IGF ...
Hormones e.g. ACTH, strogen, growth hormone...
Contact with basement membranes & adjacent
cells
Signalling through integrins
Mitotic
figures
FIBROUS REPAIR:
The development of a fibrous scar.
Rabbit ear chamber example.
Inflammation
No necrosis Necrosis
Tissue of Tissue of
Exudate Exudate
stable or permanent
resolved organised labile cells cells
Framework Framework
intact destroyed
Regeneration
Normal
structure SCARRING
(RESOLUTION)