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Age- yr 66 66
Blood pressure - mm Hg 139/79 139/79
Heart rate - beats/min 69 69
Female sex - % 27.5 25.8
History of CAD - % 79.5 81.3
Stroke or TIA - % 10.8 11.0
Peripheral vascular disease - % 42.3 44.8
Hypertension - % 47.6 46.1
Diabetes - % 38.9 38.0
Documented elevated TC - % 65.4 66.4
Documented low HDL - % 18.1 19.0
Current cigarette smoking - % 13.9 14.5
LVH on ECG - % 8.2 8.7
N Engl J Med, January 20, 2000
HOPE - Baseline Characteristics
- Medications -
Medications - %
Beta-blockers 39.2 39.8
ASA or other platelet agents 75.3 76.9
Lipid-lowering agents 28.4 28.8
Diuretics 15.3 15.2
CCBs 46.3 47.9
P<0.001
0.1
0.05
0
0 500 1000 15000
Days of Follow-up
N Engl J Med, January 20, 2000
HOPE - Primary Endpoint Results
0
MI/Stroke/ CV Death MI Stroke Non CV Death Total
CV Death Mortality
N Engl J Med, January 20, 2000
HOPE - Secondary and Other Endpoint
Results
Endpoint Ramipril Placebo RR P value
(n=4645) (n=46532)
Secondary Outcomes - %
Revascularization 16.0 18.6 0.84 <0.001
Hospitalization for UA 12.2 12.4 0.98 0.68
Complications/DM 6.2 7.4 0.84 <0.03
Hospitalization for HF 3.3 3.8 0.87 0.19
Other Outcomes - %
Heart failure 9.2 11.7 0.77 <0.001
Cardiac arrest 0.8 1.2 0.63 0.03
Worsening angina 23.8 26.2 0.89 0.003
New diagnosis of DM 3.7 5.3 0.68 0.002
Unstable angina with
ECG changes 3.9 4.0 0.96 0.72
UA = unstable angina; DM = diabetes mellitus; HF = heart failure
N Engl J Med, January 20, 2000
HOPE - Secondary and Other Endpoint
Results
25
16% Risk Reduction
p<0.001 Ramipril
20 18.6 Placebo
16 23% Risk Reduction
% with an event
p<0.001
15
16% Risk Reduction 11.7
p=0.03 9.2 32% Risk Reduction
10
7.4 13% Risk Reduction p=0.002
6.2 p=0.19
5.3
5 3.3 3.8 3.7
15 13.6 13.5
30% Risk Reduction
p=0.0032 10.3
10 33% Risk Reduction
7 p=0.010
5 4.2
5 2.9
0
MI/Stroke/ CV Death MI Stroke
CV Death
G. Dagenais, ESC 1999
HOPE - Results in Patients with Diabetes
15
38% Risk Reduction
9.6
10
6
5
0
MI/Stroke/CV Death CV Death
Vitamin E Placebo RR
*A reduction of 2 mm Hg in diastolic blood pressure (as seen in this trial) might at best
account for about 40% of the reduction in the rate of stroke and about 25% of the reduction of MI.
N Engl J Med, January 20, 2000
HOPE - Summary of Results (continued)