Hypofunction of the

Thyroid
Congenital Hypothyroidism
Epidemiology
1 out of 3000 infants worldwide
2x more in females than males
transient: matl TSH-R blocking
Ab/antithyroid drugs
80-85% - thyroid gland dysgenesis
10-15% - inborn errors of TH synthesis
5%- TSH-R Ab-mediated
2x more common in girls
Mutations; Idiopathic
 Etiology
THYROID DYSGENESIS
aplasia, hypoplasia, ectopic gland
33% - no remnants
65% - rudiments in ectopic locations
cause: unknown (sporadic or familial0