A cell which has abundant eosinophilic

cytoplasm and is strongly positive for

GFAP (glial fibrillary acidic protein) is
most likely a

(A) gemistocyte
(B) microglial cell
(C) oligodendroglial cell infected with
JC virus
(D) reactive ependymal cell
(E) "red neuron"
A 17-year-old man strikes his head and
becomes unconscious for 10 minutes following a
automobile accident. A skull fracture is
present. He recovers without any clinical
residua. The blow resulted in a 2 mm area of
superficial hemorrhage within his cerebral
cortex. Which central nervous system cell is
most likely to undergo hypertrophy and
hyperplasia as a response to the injury?
(A) astrocyte
(B) ependymal
(C) neuron
(D) oligodendrocyte
(E) Purkinje
Over a period of several years, a 70-year-old man
develops progressive dementia. He dies of pneumonia.
The accompanying photograph illustrates his brain as
found at autopsy. Which of the following would be
the abnormality expected in microscopic examination
of his brain?
(A) collection of lymphocytes in perivascular spaces
(B) cortical neurofibrillary tangles
(C) decreased pigmentation of the substantia nigra
(D) glioblastoma multiforme of the cerebral cortex
(E) stenosis of the aqueduct of Sylvius
The most common origin of brain
metastases in adults is

(A) breast carcinoma

(B) bronchogenic carcinoma
(C) colon carcinoma
(D) malignant melanoma
(E) prostatic carcinoma
A 62-year-old woman has had the slow onset over
several years of a condition which has resulted in
a diminished facial expression, stooped posture,
slowness of voluntary movement, progressively
shortened, accelerated steps and a tremor. The
patient dies of bronchopneumonia. Which one of
the following autopsy findings is most likely in the
substantia nigra of this patient?

(A) amyloid deposit

(B) decreased pigmentation
(C) dystrophic calcification
(D) necrosis
(E) negri bodies
In patients with Parkinson syndrome,
dopamine is decreased at which of the
following sites?

(A) caudate nucleus and putamen

(B) dentate nucleus
(C) globus pallidus
(D) red nucleus
(E) subthalamic nucleus
Which neoplasms are more frequent in
children than adults?

(A) astrocytoma and oligodendroglioma

(B) craniopharyngioma and glioblastoma
(C) glioblastoma and schwannoma
(D) hemangioblastoma and pituitary
adenoma
(E) medulloblastoma and ependymoma
A common site of early involvement by
multiple sclerosis is the

(A) olfactory bulb

(B) optic nerve
(C) Purkinje cell layer of cerebellum
(D) sciatic nerve
(E) ulnar nerve
A 45-year-old man has had wasting and
weakness of both hands over the last
five months. Of the following, the most
likely diagnosis is

(A) amyotrophic lateral sclerosis

(B) arteriosclerotic vascular disease
(C) Monckeberg medial calcific sclerosis
(D) multiple sclerosis
(E) syringomyelia
Which of the following types of
traumatic head injuries usually poses the
most immediate threat to life?

(A) concussion
(B) contusion
(C) subarachnoid hemorrhage
(D) subdural hematoma
(E) epidural hematoma