Mekanismekontraksiototrangka

Skeletal muscle contraction
All images in this document is removed due to copyright

restriction
Ahmad Aulia Jusuf

Nani Cahyani Sudarsono
Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006
Fungsi utama otot sebagai penggerak tubuh melalui kontraksi serat

otot yang menghasilkan kekuatan/tegangan otot (muscle tension)
Anatomi mikroskopik otot hubungannya dengan 3 unit organisasi:
Konduksi sarkolema
Kontrol retikulum sarkoplasmik
Kontraksi miofibril
Dasar molekuler kontraksi otot: proses sliding of myofilaments
secara berulang pada keadaan cukup tersedia ATP dan ion Ca
Metabolisme kontraksi otot.
Jenis serat otot serta perannya dalam gerakan tubuh.
Pengendalian gerakan tubuh.
muscle moves the body
through skeletal muscle contraction

that produce muscle tension
Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings







Sarcomere

molecular basis of muscle

contraction:
repeated sliding of myofilaments at
sufficient ATP and Ca



Muscle contraction animation:
San Diego State University College of Sciences
Based in part on
Color Atlas of Physiology, Agamemnon Despopoulos, Stefan Silbernagl
Thieme Medical Publishers, Inc. , 1991, New York

http://home.earthlink.net/~dayvdanls/biology1_2/physiolect8.htm

contraction
Metabolism for muscle
Contraction
Muscle Metabolism: Energy for
Energy for Contraction
Vander, Sherman, Luciano's Human Physiology: The Mechanisms of Body Function, 9/e
Energy for Contraction:

ATP & Phosphocreatine

Muscle Proteins
(http://www.chemsoc.org/exemplarchem/entries/kscott/images/titin.gif)
(http://www.chemsoc.org/exemplarchem/entries/kscott/images/titin.gif)
Copyright 2001-2004, E.C. Niederhoffer. All Rights Reserved .
Dystrophin Function
Protein similarity
-actinins
spectrins
Functional domains
amino terminus - 240 aa, binds F-actin
coiled-coiled rod - 2400 aa, longest section provides flexibility and elasticity
cysteine-rich - 280 aa, required for membrane attachment to -dystroglycan
carboxy terminus - 420 aa, contains potential phosphorylation sites, binds to syntrophins
Function
mechanical reinforcement of sarcolemma (in skeletal muscle)
signal transduction (control of muscle fiber caliber and size)
anchor or stabilizer of dystroglycans and sarcoglycans

Metabolic Pathways
Glucose
glycolysis (TCA cycle)
glycogenolysis (TCA cycle)
Fatty acids
-oxidation (TCA cycle)
Metabolic Pathways
Metabolic Pathways
Metabolic Pathways
Nelson, D. L., and M. M. Cox. 2000. Lehninger principles of

biochemistry, 3rd ed., p. 604. Worth Publishers, New York.
Role of Calcium
Muscle contraction
troponin C
Glycogen breakdown
calmodulin (activates phosphorylase b
kinase)
Citric acid cycle activation
pyruvate dehydrogenase complex
isocitrate dehydrogenase
-ketoglutarate dehydrogenase
Role of Calcium
movement
Muscle fiber and its role in
dalam gerakan tubuh

Jenis serat otot serta perannya
Fiber Contraction Speed:

Fast & Slow Twitch muscle fibers

RED muscle fiber
Glycogen? <<
Myoglobin? >>
Capillary? >>
Diameter? <<
Metabolism?
Myosin ATPase activity?
Time to develop max tension?
Ca++-ATPase activity in SR?
Contraction duration?
Endurance?
Use?
WHITE muscle fiber
Glycogen? >>
Myoglobin? <<
Capillary? <<
Diameter? >>
Metabolism?
Myosin ATPase activity?
Time to develop max tension?
Ca++-ATPase activity in SR?
Contraction duration?
Endurance?
Use?
Pengendalian gerakan tubuh

Control of movement
Graded Muscle Responses

Graded muscle responses are:
Variations in the degree of muscle contraction
Required for proper control of skeletal
movement
Responses are graded by:
Changing the frequency of stimulation
Changing the strength of the stimulus
Elaine N. Marieb Human Anatomy & Physiology, Sixth Edition

Treppe: The Staircase Effect

Figure 9.16
Stimulus Intensity and Muscle
Tension

Figure 9.15 (a, b)
Recruitment of Fibers: Graduated Force

Coordinating the Fibers:
Summation to Tetanus
Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings Figure 12-17: Summation of contractions
KONTRAKSI OTOT
SARAF MOTORIK
POWER STROKE
CROSS BRIDGE
GAYA MEKANIK
FREKUENSI &
INTENSITAS
PERANGSANGAN
GERAKAN
TUBUH

Mekanismekontraksiototrangka

Enviado por

Dados do documento

Título original

Direitos autorais

Formatos disponíveis

Compartilhar este documento

Compartilhar ou incorporar documento

Opções de compartilhamento

Você considera este documento útil?

Este conteúdo é inapropriado?

Direitos autorais:

Formatos disponíveis

Mekanismekontraksiototrangka

Enviado por

Direitos autorais:

Formatos disponíveis

Skeletal muscle contraction

All images in this document is removed due to copyright

Ahmad Aulia Jusuf

Fungsi utama otot sebagai penggerak tubuh melalui kontraksi serat

muscle moves the body

through skeletal muscle contraction

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

molecular basis of muscle

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Energy for Contraction

Energy for Contraction:

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

amino terminus - 240 aa, binds F-actin

cysteine-rich - 280 aa, required for membrane attachment to -dystroglycan

mechanical reinforcement of sarcolemma (in skeletal muscle)

signal transduction (control of muscle fiber caliber and size)

anchor or stabilizer of dystroglycans and sarcoglycans

Copyright 2001-2004, E.C. Niederhoffer. All Rights Reserved .

Nelson, D. L., and M. M. Cox. 2000. Lehninger principles of

dalam gerakan tubuh

Fiber Contraction Speed:

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

RED muscle fiber

WHITE muscle fiber

Pengendalian gerakan tubuh

Graded Muscle Responses

Elaine N. Marieb Human Anatomy & Physiology, Sixth Edition

Treppe: The Staircase Effect

Elaine N. Marieb Human Anatomy & Physiology, Sixth Edition

Elaine N. Marieb Human Anatomy & Physiology, Sixth Edition

Recruitment of Fibers: Graduated Force

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Você também pode gostar