Escolar Documentos
Profissional Documentos
Cultura Documentos
*APR Lecture
PowerPoint
The Autonomic
Nervous System and
Visceral Reflexes
*See separate FlexArt PowerPoint slides for all
figures and tables preinserted into PowerPoint
without notes.
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Introduction
Autonomic means self-governed and fully
independent
It regulates fundamental states and life processes
such as heart rate, BP, and body temperature
Walter Cannon coined the terms homeostasis
and the flight-or-fight reaction, dedicated to his
career in the study of ANS
15-2
General Properties of the Autonomic
Nervous System
15-3
General Properties of the Autonomic
Nervous System
Autonomic nervous system (ANS)a motor
nervous system that controls glands, cardiac
muscle, and smooth muscle
Also called visceral motor system
Primary organs of the ANS
Viscera of thoracic and abdominal cavities
Some structures of the body wall
Cutaneous blood vessels
Sweat glands
Piloerector muscles
15-4
General Properties of the Autonomic
Nervous System
Autonomic nervous system (ANS) (cont.)
Carries out actions involuntarily: without our
conscious intent or awareness
Visceral effectors do not depend on the ANS to
function; only to adjust their activity to the bodys
changing needs
Denervation hypersensitivityexaggerated
response of cardiac and smooth muscle if
autonomic nerves are severed
15-5
Visceral Reflexes
Visceral reflexesunconscious, automatic,
stereotyped responses to stimulation involving
visceral receptors and effectors and somewhat slower
responses
Visceral reflex arc
Receptors: nerve endings that detect stretch, tissue damage,
blood chemicals, body temperature, and other internal stimuli
Afferent neurons: leading to the CNS
Interneurons: in the CNS
Efferent neurons: carry motor signals away from the CNS
Effectors: that make adjustments
ANS modifies effector activity
15-6
Visceral Reflexes
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
blood pressure
Example of homeostatic
Terminal
ganglion
15-7
Figure 15.1
Divisions of the ANS
Two divisions innervate same target organ
May have cooperative or contrasting effect
Prepares body for physical activity: exercise, trauma,
arousal, competition, anger, or fear
Increases heart rate, BP, airflow, blood glucose levels, etc.
Reduces blood flow to the skin and digestive tract
Parasympathetic division
Calms many body functions reducing energy expenditure
and assists in bodily maintenance
Digestion and waste elimination
Resting and digesting state
15-8
Divisions of the ANS
Autonomic tonenormal background rate of
activity that represents the balance of the two
systems according to the bodys changing
needs
Parasympathetic tone
Maintains smooth muscle tone in intestines
Holds resting heart rate down to about 70 to 80 beats per
minute
Sympathetic tone
Keeps most blood vessels partially constricted and maintains
blood pressure
Sympathetic division excites the hearts but
inhibits digestive and urinary function, while
parasympathetic has the opposite effect 15-9
Autonomic Output Pathways
ANS has components in both the central and
peripheral nervous systems
Control nucleus in the hypothalamus and other
brainstem regions
Motor neurons in the spinal cord and peripheral ganglia
Nerve fibers that travel through the cranial and spinal
nerves
Somatic motor pathway
A motor neuron from the brainstem or spinal cord
issues a myelinated axon that reaches all the way to
the skeletal muscle
15-10
Autonomic Output Pathways
Autonomic pathway
Signal must travel across two neurons to get to the
target organ
Must cross a synapse where these two neurons meet
in an autonomic ganglion
Presynaptic neuron: the first neuron has a soma in
the brainstem or spinal cord
Synapses with a postganglionic neuron whose axon
extends the rest of the way to the target cell
15-11
Autonomic Output Pathways
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Somatic efferent innervation
ACh
Myelinated
fiber
Somatic effectors
(skeletal muscles)
ACh
ACh or NE
Myelinated Unmyelinated
preganglionic fiber postganglionic fiber Visceral effectors
(cardiac muscle,
smooth muscle,
glands)
Autonomic
ganglion Figure 15.2
ANStwo neurons from CNS to effectors
Presynaptic neuron cell body is in CNS
Postsynaptic neuron cell body is in peripheral ganglion 15-12
Anatomy of the Autonomic
Nervous System
Expected Learning Outcomes
Identify the anatomical components and nerve
pathways of the sympathetic and parasympathetic
divisions.
Discuss the relationship of the adrenal glands to the
sympathetic nervous system.
Describe the enteric nervous system of the digestive
tract and explain its significance.
15-13
The Sympathetic Division
Also called the thoracolumbar division because it arises
from the thoracic and lumbar regions of the spinal cord
Relatively short preganglionic and long postganglionic
fibers
Preganglionic neurosomas in lateral horns and nearby
regions of the gray matter of spinal cord
Fibers exit spinal cord by way of spinal nerves T1 to L2
Lead to nearby sympathetic chain of ganglia (paravertebral
ganglia)
Series of longitudinal ganglia adjacent to both sides of the vertebral
column from cervical to coccygeal levels
Usually 3 cervical, 11 thoracic, 4 lumbar, 4 sacral, and 1 coccygeal
ganglion
Sympathetic nerve fibers are distributed to every level of the body
15-14
Sympathetic Chain Ganglia
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Soma of
preganglionic
neuron
To iris, salivary glands,
lungs, heart, thoracic
blood vessels, esophagus
Sympathetic nerve
2 Spinal nerve
Somatic
motor fiber Preganglionic
sympathetic fiber
Postganglionic
sympathetic fiber
To sweat glands,
To somatic effector piloerector muscles,
(skeletal muscle) 1 and blood vessels
Soma of of skin and
somatic motor skeletal muscles
neuron
3 White ramus
Communicating
Splanchnic nerve Gray ramus rami
Preganglionic neuron
Soma of
Postganglionic neuron postganglionic
Collateral ganglion neuron
Somatic neuron Sympathetic
Postganglionic
sympathetic fibers trunk
15-16
The Sympathetic Division
After entering the sympathetic chain, the
postganglionic fibers may follow any of three
courses
Some end in ganglia which they enter and synapse
immediately with a postganglionic neuron
Some travel up or down the chain and synapse in
ganglia at other levels
These fibers link the paravertebral ganglia into a chain
Only route by which ganglia at the cervical, sacral, and
coccygeal levels receive input
Some pass through the chain without synapsing
and continue as splanchnic nerves
15-17
The Sympathetic Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Division Eye
Nasal glands
Pons
Salivary glands
Preganglionic neurons
Thoracic
Lumbar
Sacral
Lung
Celiac
ganglion
Spleen
Pancreas
Postganglionic fibers to
skin, blood vessels,
adipose tissue Inferior Small intestine
mesenteric
ganglion
Large intestine
Kidney
Ovary
15-18
Sympathetic Division
The Sympathetic Chain Ganglia
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Cardiac n.
Thoracic
ganglion
Communicating Bronchi
ramus
Superior
Sympathetic vena cava
chain
Rib
Splanchnic n.
Phrenic n. Heart
Vagus n.
Diaphragm
From A Stereoscopic Atlas of Anatomy by David L. Basett. Courtesy of Dr. Robert A. Chase, MD.
15-20
Figure 15.3
The Sympathetic Division
15-21
The Sympathetic Division
Routes (cont.)
Routes (cont.)
15-23
The Sympathetic Division
Collateral ganglia contribute to a network called
the abdominal aortic plexus
Wraps around abdominal aorta
Three major collateral ganglia in this plexus
Celiac, superior mesenteric, and inferior
mesenteric
Postganglionic fibers accompany these arteries and
their branches to their target organs
Solar plexus: collective name for the celiac and
superior mesenteric ganglia
Nerves radiate from ganglia like rays of the sun
15-24
The Sympathetic Division
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Diaphragm
Esophagus
Adrenal medulla
Adrenal cortex
Adrenal gland
Celiac trunk
Superior mesenteric
ganglion
Renal plexus
Inferior mesenteric
ganglion
Aorta
Pelvic
Figure 15.6
sympathetic
chain
15-25
(a)
The Sympathetic Division
15-26
The Adrenal Glands
15-27
Adrenal (Suprarenal) Glands
Adrenal (Suprarenal) Glands
Cortex & Medulla
Capsule Cortex
Medulla
Suprarenal Gland
Low Magnification
Capsule of
suprarenal gland Zona glomerulosa
15-31
The Parasympathetic Division
15-32
The Parasympathetic Division
Pathways of long preganglionic fibers
Fibers in cranial nerves III, VII, IX, and X
Fibers arising from sacral spinal cord
Pelvic splanchnic nerves and inferior hypogastric
plexus
Terminal ganglia in or near target organs
Long preganglionic, short postganglionic fibers
Neuronal divergence less than sympathetic
division
One preganglionic fiber reaches the target organ
and then stimulates fewer than five postganglionic
cells 15-33
Parasympathetic Cranial Nerves
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Preganglionic neurons
Pterygopalatine
Oculomotor n.
Ciliary ganglion Lacrimal gland
(CN III)
Eye
Facial n.
(CN VII)
Submandibular
Narrows pupil and focuses lens
ganglion
Submandibular
Parotid
Glossopharyngeal n.
salivary gland
(CN IX)
Vagus n.
(CN X) Tear, nasal, and salivary glands
Heart
Cardiac plexus
Regions of
spinal cord
Pulmonary
plexus Glossopharyngeal nerve (IX)
Esophageal
Lumbar Celiac
ganglion Stomach
Sacral
Transverse
colon
colon
Inferior Descending
esophageal plexus
Rectum
Pelvic
nerves
Figure 15.7
Penis Bladder
Ovary
15-34
Scrotum
Uterus
Parasympathetic Division
The Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Parasympathetic Pterygopalatine
ganglion
Preganglionic neurons
Postganglionic neurons
Division
Oculomotor n.
Ciliary ganglion Lacrimal gland
(CN III)
Eye
Facial n.
(CN VII)
Submandibular
ganglion
Heart
Cardiac plexus
Pulmonary
Esophageal
Lumbar Celiac
Abdominal
aortic
Stomach
Liver and
gallbladder
plexus
Spleen
Kidney and
Transverse
colon
Scrotum
Uterus
15-36
The Enteric Nervous System
Enteric nervous systemthe nervous system of the
digestive tract
Does not arise from the brainstem or spinal cord
Does innervate smooth muscle and glands
15-39
Neurotransmitters and Their Receptors
How can different autonomic neurons have different effects
constricting some vessels but dilating others?
Effects determined by types of neurotransmitters released and
types of receptors found on target cells
15-40
Neurotransmitters and Their Receptors
15-41
Neurotransmitters and Their Receptors
15-42
Neurotransmitters and Their Receptors
NE is secreted by nearly all sympathetic
postganglionic neurons
Called adrenergic fibers
Receptors for it called adrenergic receptors
Alpha-adrenergic receptors
Usually excitatory
Two subclasses use different second messengers (1 and
2)
Beta-adrenergic receptors
Usually inhibitory
Two subclasses with different effects, but both act through
cAMP as a second messenger (1 and 2)
15-43
Neurotransmitters and Their Receptors
Autonomic effects on glandular secretion are often
an indirect result of their effect on blood vessels
Vasodilation: increased blood flow; increased secretion
Vasoconstriction: decreased blood flow; decreased
secretion
Nicotinic
receptor
ACh
Target
cell
ACh
Preganglionic Postganglionic Muscarinic
neuron neuron receptor
Nicotinic
receptor
ACh
Target
cell
Preganglionic NE
neuron
Postganglionic Adrenergic receptor
neuron
Nicotinic
receptor
ACh
Target
cell
Preganglionic
neuron
Postganglionic
ACh
Muscarinic receptor
Figure 15.8
neuron 15-46
Dual Innervation
Dual innervationmost viscera receive nerve
fibers from both parasympathetic and
sympathetic divisions
Antagonistic effect: oppose each other
Cooperative effects: two divisions act on different
effectors to produce a unified overall effect
15-47
Sympathetics & Parasympathetics
Dual Innervation
Antagonistic effectsoppose each other
Exerted through dual innervation of same effector cells
Heart rate decreases (parasympathetic)
Heart rate increases (sympathetic)
15-49
Dual Innervation
15-50
Dual Innervation of the Iris
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Brain
Parasympathetic fibers
of oculomotor nerve (III)
Sympathetic
fibers
Superior
cervical
ganglion
Ciliary
ganglion
Spinal cord
Cholinergic stimulation
of pupillary constrictor
Iris
Adrenergic
stimulation of Pupil
pupillary dilator
Sympathetic Parasympathetic
(adrenergic) effect (cholinergic) effect
Figure 15.9
15-51
Pupil dilated Pupil constricted
Control Without Dual Innervation
15-52
Control Without Dual Innervation
Sympathetic vasomotor tonea baseline firing
frequency of sympathetics
Keeps vessels in state of partial constriction
Increase in firing frequencyvasoconstriction
Decrease in firing frequencyvasodilation
Can shift blood flow from one organ to another as
needed
Sympathetic division acting alone can exert opposite
effects on the target organ through control of blood
vessels
During stress
Blood vessels to muscles and heart dilate
Blood vessels to skin constrict
15-53
Control Without Dual Innervation
Copyright The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Sympathetic
(a) Vasoconstriction
vasoconstrict to
1 Weaker
minimize bleeding if 2
sympathetic
tone
stress or exercise
3 Vasodilation
(b) Vasodilation
15-54
Figure 15.10
Central Control of Autonomic
Function
15-55
Central Control of Autonomic
Function
ANS regulated by several levels of CNS
Cerebral cortex has an influence: anger, fear, anxiety
Powerful emotions influence the ANS because of the
connections between our limbic system and the
hypothalamus
Hypothalamus: major visceral motor control center
Nuclei for primitive functionshunger, thirst, sex
15-56
Central Control of Autonomic
Function
ANS regulated by several levels of CNS (cont.)
Midbrain, pons, and medulla oblongata contain:
Nuclei for cardiac and vasomotor control, salivation,
swallowing, sweating, bladder control, and pupillary changes
Spinal cord reflexes
Defecation and micturition reflexes are integrated in spinal
cord
We control these functions because of our control over
skeletal muscle sphincters; if the spinal cord is damaged,
the smooth muscle of bowel and bladder is controlled by
autonomic reflexes built into the spinal cord
15-57
Drugs and the Nervous System
15-58
Drugs and the Nervous System
Parasympathomimetics enhance activity while
parasympatholytics suppress activity
NH2
N N O CH3
H3C
N N
N N
OH O N
O N
CH3
OH OH
Adenosine Caffeine