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WISTIANI
UKK Alergi & Imunologi
IKATAN DOKTER ANAK INDONESIA
30 Juli 2017
Dr. Wistiani, SpA(K), MSi Med
Kepala Divisi Alergi-Imunologi
Departemen Ilmu Kesehatan Anak RSUP Dr. Kariadi/FK UNDIP
Newborn:
Acquired IgG transplacenter at adult levels
Small amounts of IgM
IgA synthesis at 2-3 weeks postnatal
Poor antibody response following immunization
susceptibility to viral infection
Kesehatan
Lahir Dewasa
Pertumbuhan & metabolisme Stunting
Kualitas
Pematangan sal cerna Alergi
hidup
Perkembangan otak dan saraf Obesity
Pematangan imunitas Penyakit Jantung
Pengenalan rasa dini Diabetes
Penurunan fungsi kognitif
The impact of breastmilk in the development of infants immune
system
Human breastmilk contains numerous protective factors against infectious disease developing infant
immune system
Premature discontinuation of breastfeeding may predispose to chronic disease in later life (allergy,
autoimmune)
It helps to shape infant mucosal gi tract immunity
Factors shaping neonatal microbiome
Infants who are breastfed showed larger thymus glands thus it has direct effect on T
lymphocytes development (Hasselbalch H, et al. Acta Paediatr 1996;85)
It antibodies confer defence aginst every disease the mother has ever been exposed to
provide a dynamic maternal immune protection nurtured transmitted to the suckling
infants
Role of NK cells
Schematic graph of the different arms of the immune response to influenza over the lifetime of an
individual
Principles of vaccination:
1. Goal: to provide protective immunity by inducing a memory response
2. The antibodies are effective primarily against extracellular organisms and their products
3. Cell-mediated immunity is important in preventing intracellular bacterial or viral and fungal
infection goal: eradication of disease
NEW APPROACH: New vaccine strategies for the immunotherapy
and prevention of cancer
Old approach (non-surgical) on cancer therapy:
Treatment
Allergy trace Primary prevention: Re-exposure with
-Allergen
card -Exclusive the same allergen
identification
breastfeeding
- Hydrolyzed
- Avoid cigarette Secondary
formula, AAF, Soya
smoke prevention
- Immunotherapy
- If BF (-) partially
hydrolized formula
Identification of allergen
Avoidance
Pediatr Allergy Imunol 2008;19
5. The association of immune system & gut microbiota
growth in early life
Tsuji NM, Kosaka A. Oral tolerance : intestinal homeostasis and antigen-specific regulatory T cells. Trends in Immunology, vol 29 No. 11, 2008
Role of foods on immune function modulation
IDAI, 2010
Protein Hydrolysates: Different
Types
Prevention
Allergenicity
Role of iron supplementation
on health and disease
8. Nutrition management for allergy (prevention and management), IDAI
algorithm
TATALAKSANA ALERGI
SUSU SAPI PADA BAYI
DENGAN ASI
TATALAKSANA ALERGI
SUSU SAPI PADA BAYI
DENGAN SUSU
FORMULA
CONCLUSION
Effective nutritional interventions in the immune system
may find value not only in therapeutic approach but also in
the prophylactic treatment of subjects with risk of immune
dysfunction
The evolution of the immune system in individual possibly
reflects the central role of individu in the survival from
pathogen
Micronutrients and other food components are play role in
the development of immune system
Issues of pro/pre/synbiotics role on immune system still
need further studies to confirmed the mechanisms on
shaping human immune system
THANK YOU
wistiani@yahoo.com