GLYCOSYLATION

THE THIRD GROUP

Post-Translational Modification

Post-Translational Modification (PTM)

is the chemical modification of a protein
after its translation.
Types of Post-Translational Modification
 What is the Glycosylation?

Glycosylation is a critical function of

the biosynthetic-secretory pathway in the
endoplasmic reticulum and Golgi
apparatus. Glycosylation is a process the
attachment of sugar moieties to proteins
 N-linked glicans

Types of O-linked glicans

Glycosylation

C-linked glicans
 N-linked glicans

Attached to amide
nitrogen of an
asparagine
Occurs in the lumen
of the endoplasmic
reticulum in
eukaryotes
 O-linked glicans

Attachment of
carbohydrate to
serine or
threonine
Occurs in the golgi
apparatus
 C-linked glicans

C-Mannosylation
features a unique
C-C bond linking
C1 of Mannose to
C2 of the indole
ring of tryptophan.
Take place in ER.
Process of Glycosylation
Known Sorting Signals That Direct Proteins to
Specific Transport Vesicles
Coated Vesicles Involved in Protein
Trafficking
Process of Glycosylation
Process of Glycosylation
Process of Glycosylation
Process of Glycosylation
Process of Glycosylation
Process of Glycosylation
Process of Glycosylation
GOMAWO