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Mechanism of Pharmacokinetics
Bioavailability
Liver
Kidneys
Intestine
Adrenal cortex
Lungs
Placenta
Skin
Process
Drug enters the liver
Form as metabolites
Drugs which
undergoes
biotransformation
reaction became less
Systemic circulation lipid soluble, hence
not be reabsorbed
from renal tubules
and get excreted
Site of action
Contd.
Epinephrine
Pentobarbital MAO
Hydroxypentobarbital vinyl mendalic acid
Morphine
Alcohol
Nor morphine
Codeine AD
Morphine acetaldehyde
Reduction
Cortisone
Hydroxycortisone
Hydrolysis
Microsomal hydrolysis-
Esterase
Pethidine Pethidinic acid
Paracetamol
Aspirin
Sulfonamides
Enzyme inducer
Ex- Unwanted pregnancy can results even in the use of oral
contraceptive pills comitantly with phenytoin or rifampacin