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Pertemuan 2-3
Alcohols and Ethers
Prof. Dr. Adel Zamri, MS, DEA
Ihsan Ikhtiarudin, M.Si
DEPARTMENT OF CHEMISTRY
FACULTY OF MATHEMATICS AND NATURAL SCIENCES
UNIVERSITY OF RIAU
PEKANBARU
2015
Introduction
Alcohols
Ethers
Medicinal Research
Anesthetic
Nomenclature
Nomenclature of Alcohol:
2. H2S, H2O OH
Cis-1,2-cyclohexanediol
R PBr3
OH R
Br
R F3CSO2Cl X
OH R SO2CF3 R
O X
R Ts-Cl X R
OH R Ts
O X
R SOCl2 R
OH Cl + SO2 + HCl
O O
SOCl2
+ SO2 + HCl
R OH R Cl
Other way to displace hydroxy
with halogen: using ZnCl2
Starting with alcohol, outline a synthesis of each
of the following:
a. Benzyl bromide
b. Cyclohexyl chloride
c. butyl bromide
Dehydration of Alcohol:
Synthesis Alkene
Dehydration with rearangement
Problem
Problem
Preparation of Ethers form Alcohols
The Williamson Ether Synthesis
Alcohols and Ethers from Epoxides
Reactions of Ethers with HCl/HBr
HBr excess condition:
Examination
Learn The
Mechanism!
Oxidation and Reduction of Alcohols
Strong Oxidizing Agents
Jones Reagent : Strong Oxidizing Agent
Problem
Additional Methods for oxidizing Alcohol
Oxidation with KMnO4 and HNO3
Oxidation with CuO
Swern Oxidation
Problem
Solved Problem
Problem
Reduction of Alcohols
Problem
Mechanism
References: