ANALISIS KRITIS JURNAL Penyusun :

1. Evi Ristiana A. (16431008)

BIOLOGI SEL 2. Raden Yusuf A (16431015)

3. Nova Hartina (16431026)
BILIOGRAFI JURNAL NASIONAL
Sukardiman, Abdul Rahman, Wiwied Ekasari dan Sismindari. 2005. Induksi Apoptosis
Senyawa Andrografolida dari Sambiloto (Andrographis paniculata Nees) terhadap Kultur Sel
Kanker. Yogyakarta. Vol. 21, No. 3, September 2005
KESIMPULAN
Pemberian andrografolida pada kultur sel HeLa (sel kanker) dapat menyebabkan
terjadinya induksi apoptosis.
Senyawa andrografolida yang memiliki aktivitas sebagai inhibitor terhadap aktivitas
enzim DNA topoisomera-se II

Fungsi enzim DNA topoisomerase mempunyai fungsi yang penting dalam proses
intraseluler yaitu berperan dalam proses replikasi, transkripsi, rekombinasi DNA dan
proses proliferasi dari sel kanker.
BILIOGRAFI JURNAL INTERNASIONAL
Jayashree Bagcy C., Fiona O., Meagan J. Wals. 2012. Mechanisms and Biomarkers of
Apoptosis in Liver Disease and Fibrosis. UK: International Journal of Hepatology. Volume
2012, Article ID 648915, 10 pages.
CONCLUTION
Apoptosis can occur in response to viral infection, and exposure to any kind of
hepatocarcinogen, excessive alcohol consumption or due to genetic mutations.

Apoptosis is also the main mechanism promoting the resolution of fibrosis, and
spontaneous or targeted apoptosis of HSC is associated with regression of fibrosis in
animal models and patients with chronic liver disease.

Pathophysiological role of apoptosis is implicated in a number of liver diseases

and contributes directly to fibrogenesis.