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Definisi
• Hashimoto’s disease is an autoimmune
disorder that can cause hypothyroidism, or
underactive thyroid. With this disease,
your immune system attacks your thyroid. The
thyroid becomes damaged and can’t make
enough thyroid hormones.
Epidemiologi
• Hashimoto’s disease is the most common
cause of hypothyroidism in the United States,
and affects about 5 people out of 100.
Etiologi
• Hashimoto’s disease is at least 8 times more
common in women than men. Although the
disease may occur in teens or young women,
it more often appears between ages 40 and
60.
• Your chance of developing Hashimoto’s
disease increases if other family members
have the disease
• You are more likely to develop Hashimoto’s disease if
you have other autoimmune disorders. Conditions
linked to Hashimoto’s disease include
• Addison’s disease
• autoimmune hepatitis
• celiac disease
• Lupus
• pernicious anemia
• rheumatoid arthritis
• Sjögren’s syndrome
• type 1 diabetes
• vitiligo
Patofisiologi
• In Hashimoto’s disease, your immune system
makes antibodies that attack the thyroid
gland. Large numbers of white blood cells
called lymphocytes, which are part of the
immune system, build up in the thyroid.
Lymphocytes make the antibodies that start
the autoimmune process.
Manifestasi Klinis
• The hypothyroidism of Hashimoto’s disease often is subclinical—mild and
without symptoms—especially early in the disease.