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Discoveries in Biology
The Story of Life: A Preview
Discoveries in Biology: The Course
• 3 credits
• No prerequisites
• Satisfies 3 of the at least 6 credits needed for
the Natural Science foundation courses in the
undergraduate curriculum
• The course will focus on important discoveries
in biology as a way of introducing students to
the concepts underlying life and their
applications in modern biotechnology
Instructor
• Ornob Alam
• B.Sc. in Biological Science from Florida State
University
• Sc.M. in Molecular Microbiology and Immunology
from Johns Hopkins Bloomberg School of Public
Health
• Research:
– Immunomodulatory effects of testosterone in
response to influenza infection (at Johns Hopkins)
– Biochemical identification of cellulolytic bacteria and
optimization of cellulase activity (at IUB)
Biology
• The study of living organisms
• But what is life?
Smithsonian Magazine
Life
• No universal agreement on what exactly
makes up life
• Most living organisms share certain features in
common:
– Processing of nutrients and energy
– Ability to adapt
– Reproduction
– More to come later
Life On Earth
• Life is endlessly diverse…
Hypothesis
Experiment
Data
Conclusion
The Scientific Method
• A hypothesis is an explanation based on
observations, which is then used as a starting
point for scientific inquiry
• Experiments are designed to test hypotheses
• A verified hypothesis becomes a theory,
whose tenets and conclusions remain open to
further testing
The Art of the Experiment
• Experiments test hypotheses in a controlled
setting
• Important concepts:
– Bias: Favoring or disfavoring something without
evidence
– Placebo effect: When a fake treatment improves a
patient’s condition because the patient expects it to
– Experiments test the effects of an independent
variable on dependent variables
– Controls are experimental duplicates in the absence
of the independent variable
Illustration through a Drug Trial
RESEARCHER
INTERMEDIARY
Drug X Placebo