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ERI KA CAPALLA
UNI VERSI TY OF SAN DI EGO
MSNC 511: EVI DENCE-BASED PRACTI CE: ROLE OF THEORY AND
RESEARCH
PICOT QUESTION
• Type
• 4 RCTs
• 1 Non-experimental study
• Level/Quality
• RCT #1: IB-good quality
• RCT #2-4: IA-high quality
• Non-experimental study: IIIB-good quality
ARTICLE CRITIQUE #1
• Neal, E.G., Chaffe, H., Schwartz, R.H., Lawson, M.S., Edwards, N.,
Fitzsimmons, G., Whitney, A., et al (2009). A randomized trial of
classical and medium chain triglyceride ketogenic diets in the
treatment of childhood epilepsy. Epilepsia, 50, 1109-1117.
• Seo, J.H.; Lee, Y.M.; Lee, J.S.; Kang, H.C.; Kim, H.D. (2007).
Efficacy and tolerability of the ketogenic diet according to
lipid: nonlipid ratios-comparison of 3:1 with 4:1 diet. Epilepsia,
48, 801-805.
• Seo, J.H., Lee, Y.M., Lee, J.S., Kang, H.C., Kim, H.D. (2005).
Fasting versus gradual initiation of the ketogenic diet: a
prospective randomized clinical trial of efficacy. Epilepsia, 46,
1810-1819.
• Nursing Research:
• Further research in long term effects
• Further research on specific seizure types
• Nursing Education:
• Nurse training re: ketogenic diet
• Nursing Practice:
• Alternative treatment
• Gradual introduction
• 4:1 diet
• Ketogenic diet effective
REFERENCES
• Neal, E.G., Chaffe, H., Schwartz, R.H., Lawson, M.S., Edwards, N., Fitzsimmons, G., et al
(2008). The ketogenic diet for the treatment of childhood epilepsy: a
randomised controlled trial. Lancet-Neurology, 7, 500-506.
• Neal, E.G., Chaffe, H., Schwartz, R.H., Lawson, M.S., Edwards, N., Fitzsimmons, G.,
Whitney, A., et al (2009). A randomized trial of classical and medium chain
triglyceride ketogenic diets in the treatment of childhood epilepsy. Epilepsia,
50, 1109-1117.
• Lambrechts, D., Kinderen, R., Vles, H., de Louw, A., Aldenkamp, A., Majoie, M. (2015). The
MCT-ketogenic diet as a treatment option in refractory epilepsy: a prospective
study with a 2 year follow up. Epilepsy and Behavior, 51, 261-266.
• Seo, J.H.; Lee, Y.M.; Lee, J.S.; Kang, H.C.; Kim, H.D. (2007). Efficacy and tolerability of the
ketogenic diet according to lipid: nonlipid ratios-comparison of 3:1 with 4:1 diet.
Epilepsia, 48, 801-805.
• Seo, J.H., Lee, Y.M., Lee, J.S., Kang, H.C., Kim, H.D. (2005). Fasting versus gradual initiation
of the ketogenic diet: a prospective randomized clinical trial of efficacy. Epilepsia,
46, 1810-1819.
QUESTIONS?