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Roll no: 24
CONTENTS
2
Introduction
Neurotrophic Hypothesis
Monoamine Hypothesis
Neuroendocrine Factors
Integration of Hypotheses
Signs and Symptoms of Depression
INTRODUCTION
3
neurogenesis; but under stress, the gene for BDNF may be repressed.
Stress can lower 5HT levels and can acutely increase, then chronically
BRAINST
deplete, both NE and DA; together with deficientEM amounts of BDNF may
lead to atrophy and possible apoptosis of DEATHvulnerable neurons in the
hippocampus and other brain areas such as prefrontal cortex.
Depression is associated with the loss ofWHOL
neurotrophic support and that
E BRAI
effective antidepressant therapies increase neurogenesis and synaptic
DEATH
connectivity in cortical areas such as the hippocampus. *2
MONOAMINE HYPOTHESIS
INTRODUCTION
5
Nonsuppression of Steroids
adrenocorticotropic Chronically elevated
WHOL levels
hormone (ACTH) release in of Corticotropin-releasing
E BRAI
the dexamethasone hormone
suppression test DEATH
INTEGRATION OF HYPOTHESES
INTRODUCTION
7
CORTICAL
OR
CEREBRAL
DEATH
BRAINST
EM
DEATH
WHOL
E BRAI
DEATH
References
9
WHOL
E
BRAIN
DEATH