Escolar Documentos
Profissional Documentos
Cultura Documentos
Disusun Oleh:
Nabilah Afifah 2011730069
Pembimbing :
dr. Rudi Darmawan Sp.P
BAGIAN INTERNA
PROGRAM PENDIDIKAN PROFESI DOKTER
FAKULTAS KEDOKTERAN
UNIVERSITAS MUHAMMADIYAH JAKARTA
RS. SEKARWANGI
2016
INTRODUCTION
STATIN
• Decreased MUS5AC gene expression – (goblet cell hyperplasia-
mucus)
• Cytoprotective effect – induction of prosolution mediator like 15-
api-lipoxin A4 (15-epi-LXA4)
• Decrease the expression of the metalloproteinases, especially MMP-
9 thus may mitigate the subepithelial fibrosis and thickening of the
basement membrane
• Inhibitors of mevalonate pathway like statins and GGTase 1 could
produce apoptosis and autophagy of the airway smooth muscle cells
and may contribute to airway remodeling
CLINICAL STUDIES
CLINICAL STUDIES
CLINICAL STUDIES
CLINICAL STUDIES
• There have been a few animal studies that have reported better results
with inhalational routes of administration of statins as compared to other
systemic routes. However, there are no published reports of other routes in
humans.
CLINICAL STUDIES