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THROMBOSIS
Disusun oleh :
Ika Lukita Sari
Definition
• DVT refers to the formation of one or more blood clots (a blood clot is also known as a
“thrombus,” while multiple clots are called “thrombi”) in one of the body’s large veins most
commonly in the lower limbs (e.g.,lower leg or calf)
• Veins are blood vessels that carry blood to the heart, from other body regions. There are
two types of veins, namely superficial veins that lie just below the skin, and deep veins,
located deep within the body (such as the leg muscles).
• Deep Vein Thrombosis (DVT) is a blood clot that occurs in a deep vein of the leg. Most of
these blood clots occur in the leg or thigh; though, they may also occur in other parts of
the body. A calf vein in the leg, is the most common site for a DVT (clot) to occur.
• When an individual suffers from such a condition, the blood flow in the vein is partially or
completely stopped by the blood clot.
Who gets Deep Vein Thrombosis? (Age and
Sex Distribution)
• Deep Vein Thrombosis can occur in any individual, at any age
• Adults, over the age of 60 years are commonly affected by this condition, with a
slightly higher male incidence
Predisposing Factors
• Risk factors that increase the incidence of Deep Vein Thrombosis are:
• Immobility: Sitting in a single place for a long time without moving the legs, can affect the
flow of blood in the veins and consequently lead to DVT, like during a long distance
air/train/car travel
• Surgical operation: During surgery, the individual is administered anesthesia and hence
remains immobilized/still, for long hours. This could cause a paralysis in some muscles and
slow down the blood flow in the veins, increasing the risk of blood clots
• Illness or injury that causes immobility for a long time duration, like a leg fracture (especially
in the long bones of the leg)
Damages caused to the inside lining of the vein due to:Inflammation of the vein wall
• Drugs taken for curing certain illnesses; chemotherapy drugs may damage the veins
• Injury to the vein caused by needle, when an intravenous catheter is inserted into a vein
Other reasons for blood clot formation may include:Nephrotic syndrome (kidney disease)
• Hormone replacement therapy: Those undergoing this therapy have a high risk of contracting Deep Vein Thrombosis
• Individuals with cancer or heart diseases, are more susceptible than othersMale adults over the age of 60 years have
a higher risk
• Pregnancy
• Dehydration
• Smoking
• Polycythemia vera: A disorder, where the bone marrow makes too many blood cells, causing the blood to become
thicker and slower
Etiology
1. When the inner lining of the veins are damaged, which may be due to physical,
chemical, and biological factors, such as:
• Surgery
• Serious injuries
• Inflammation
• Immune responses
2. Sluggishness or slowness in the flow of blood, which may be due to:
• When the blood becomes more thicker, which may be due to inherited conditions
(such as Factor V Leiden), or hormone therapy, the use of contraceptive pills, or
caused by blood-related disorders (like polycythemia vera)
Signs and Symptoms of Deep Vein
Thrombosis
• Physical examination, to check for symptoms like red, swollen, and tender calf
muscle, including evaluation of medical history
• Antiphospholipid antibodies
• Lupus anticoagulant
The major complications that might arise from Deep Vein Thrombosis are
pulmonary embolism and post-thrombotic syndrome, which are explained below:
Pulmonary embolism: A blood clot may break away and move up through the
bloodstream and block the lungs, leading to a condition known as pulmonary
embolism. Any individual with a pulmonary embolism might be at risk for the
following complications:
• Sudden cough accompanied by bloody sputum
• Pain
• Heparin is normally the first drug administered (through a vein), and this requires hospitalization
• Warfarin drug is administered orally along with heparin, and it may be continued for more than 3 months or longer
• The use of pressure stockings, which is worn on the legs, helps improve the blood flow in the legs and reduce the
complications arising out of a blood clot
• Surgery may be recommended if medicines are not helpful. The procedures may involve:
• A filter may be placed in the largest vein, in order to prevent blood clots from moving to other parts of the body, from the lungs
• The pressure stockings, prescribed by the doctor, should be worn continuously to improve blood
flow in the legs
• Try not to remain immobile for a long duration especially while traveling or taking a long drive.
Move your legs during a long plane trip or long distance drive; avoid sitting in one place for a
very long time
• Individuals having a high risk for DVT could take heparin shots (per physician’s advice), while
going on long air/car trips
• In most cases Deep Vein Thrombosis cures without any complications; however,
the risk of recurrence is always present
• Some individuals may experience long-term pain and swelling in the legs, called
postphlebtic syndrome. Sometimes, pain and changes in skin color, may also be
seen
• In some cases, the blood clots in the thighs, may break-off and travel to the lungs,
which may lead to dangerous medical issues
Additional and Relevant Useful Information
for Deep Vein Thrombosis: