CONTENTS

• DEFINITION
• INDICATION FOR OGTT
• CONTRAINDICATION FOR OGTT
• PREPARATION OF THE PATIENT
• CONDUCTING THE GLUCOSE
TOLERANCE TEST
• INTERPRETATION
 DEFINITION

• GTT is well standardised test, and is highly

useful to diagnose diabetes mellitus in doubtful
cases
• Commonly referred to as oral glucose tolerance
test (OGTT)
 INDICATION FOR OGTT

• Patient has symptoms suggestive of diabetics

mellitus
• Fasting blood sugar value is inconclusive
(between 110 and 126 mg/dl)
• During pregnancy, excessive weight gaining is
noticed, with a past history of big baby (more
than 4 kg) or past history of miscarriage
• To rule out benign renal glucosuria
 CONTRAINDICATION FOR
OGTT
• There is no indication for doing OGTT in a
person with confirmed diabetics mellitus
• GTT has no rule in follow-up of diabetics
• It is indicated only for the initial diagnosis
• The test should not be done in ill patients
 75g Oral Glucose
Tolerance Test:
Precautions/prep and
procedure
Test is performed only in ambulatory subjects
Test is not performed on hospitalized, acutely ill
or inactive subject
After 3 days of unrestricted diet ( at least 150 g of
CHO / day ) and activity
Test is performed in the morning after 12 – 14 hrs
fast
Individual should remain seated during test
without smoking cigarette.
• Test should begin between 0700 to 0900
hrs.
• 75g Glucose or 7.5g/Kg body weight is
dissolved in 300 ml of water
• Glucose is ingested over 5 minutes
• Plasma glucose is measured during
fasting followed by
• Every one hour for 2hrs after an oral
glucose load
 INTERPRETATION

• 2hPG < 140mg/dl: Normal

• 2hPG 140 – 199 mg/dl: Impaired Glucose
Tolerance (if FPG< 126mg/dl)
• 2hPG > 200mg/dl: Diabetes Mellitus
THANK YOU…