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董鴻甯 林律雅 辛怡萱 洪侊增 翁惟康

薛丞芳 邱涵晞 徐榮澤 陳韋存 辛員嘉


Sympton

A 48-year-old female complains


of lethargy, headache,
photophobia and arthralgia over
hands and feet. Her face showed
gradual enlargement in nose lip
and skin folds. Laboratory
evaluation reveals IGF-1 and GH
slight increase.
Question 1

○ Which endocrine organ is involved ?

○ IGF-1 : Liver
○ GH : Pituitary gland
○ Describe the effects of hormone from
this organ.

○ Pituitary gland
Hormone Target Function
Stimulates the adrenal gland to
ACTH Adrenals
produce cortisol
Stimulates the thyroid gland to
TSH Thyroid
secrete thyroxine
Ovaries Controls reproductive functioning
LH & FSH
Testes and sexual characteristics
Stimulates the breasts to produce
Prolactin Breasts
milk
GH Stimulates growth and repair
Controls the blood fluid and mineral
ADH Kidneys
levels in the kidneys
Affects uterine contractions in
Uterus
Oxytocin pregnancy and birth and
Breasts
subsequent release of breast milk.
Acromegaly
Hypothalamus
Pituitary adenoma Too much
GHRH

Growth hormone↑

Growth hormone ↑

Acromegaly

Tumor
Symptom
○ By too much growth hormone
○ Hands and feet become larger and broader
○ Skin thicken(especially on the face)
○ Thickened lips, nose, scalp, jaw
○ Vocal cords thicken
○ Tongue may enlarge
○ Arthralgia
○ High blood pressure
○ Diabetes
○ Carpal tunnel syndrome
Symptom

○ By the growing tumor


○ Headaches
○ Problems with vision
○ Other normal cells in the pituitary
become squashed and damaged
→ lack of other hormones
Question 2

○ What kind of test can prove it ?

1. Blood test (growth hormone & IGF-1)


2. OGTT (Oral glucose tolerance test)
3. MRI scan
4. Eye and visual test
Question 3

○ Describe the factors affecting growth


hormone secretion?

○ Growth hormone-releasing
hormone(GHRH)
○ Somatostatin
Reference

○ http://www.pituitary.org.uk/information/what-is-the-pituitary-gland/hormones/
○ http://www.slideshare.net/thelawofscience/endocrine-system-13158027
○ http://www.vupdateu.com/2012/05/pituitary-gland/
○ http://www.translational-medicine.com/content/10/1/224#sec3
○ http://www.patient.co.uk/health/acromegaly-leaflet
○ http://1.bp.blogspot.com/-
4wapBW6TWSc/T1XHLZOfGUI/AAAAAAAAAFQ/pXz6rM0Uw8A/s1600/acrotonguesid
e.jpg
○ http://static.fjcdn.com/pictures/The_d9f8f3_262074.jpg
○ http://www.51qe.cn/pic/30/12/17/32/b/15001.jpg
○ http://i3.sinaimg.cn/ent/m/2010-07-
28/U105P28T3D3032683F329DT20100728194539.jpg
○ http://www.larousse.fr/encyclopedie/data/images/1001737-
Localisation_de_lhypothalamus.jpg
○ Ganong WF. Review of Medical Physiology 21th ed. 2003. McGraw Hill