BRPHARM PDT Gel Guideline

PDT Gel
PHOTO DYNAMIC THERAPY

 Patented with BR own technology.

 Proved its effect and safety by clinical reports of several universities.
 Actively used in clinics and hospitals.
 Plenty of clinical data secured.

Medical Acne Tr e a t m e n t ! BRPHARM Co.,Ltd.

The Innovation of PDT [Photo Dynamic Therapy] & TTP [Tryptophan] www.brpharm.com
BRPHARM PDT Gel

PDT Gel
PHOTOSENSITIZER (PROFESSIONAL USE ONLY)

BR PDT GEL is highly efficient acne/sebum secretion control

solution. Fat-Soluble and stably improves troubles with fast
absorption and fast metabolism.

Tryptophan and
one acne and sebum
suppression containing
its derivatives

PDT Solution : 2ml x 5 vials

BRPHARM PDT Gel

PDT Gel
Tryptophan and its derivative in treatment of acne and controlling sebum secretion.
Patent Number : 10-1308507

What is PDT Gel?

Tryptophan is an essential amino acid as a photosensitizer.
◈ New mechanism. No need of porphine’s
◈ biosynthetic pathway. -> Reduced treatment time.
◈ Excellent bio-degradability and perfect emission. -> No side effect.
◈ Best result for post-breakout red marks and PIH. -> A multi-treatment.

• Controlling • Perfectly Safe

sebum
• Inflamed production • Supplementing • Maximum Effect
acne ALA
• Improving photosensitizer ‘s • New concept
skin pores weaknesses photosensitizer
BRPHARM PDT Gel

PDT Gel TREATMENT

Riboflavin[Vitamin B2]
Compose Coenzyme which is important to various metabolism. Activates Trytophan and brighten acne
trace and dark skin.

Tryptophan
One of standards Amino acid among 20 kinds comprising of protein.
After combining with Riboflavin, Tryptophan is changed to peroxidized tryptophan and improves chronic trouble.

Niacinamide
Multifunctional whitening ingredients. Blocks oxidization and reduce the loss of moisture.
Keeps skin health and clear tone by reducing the transportation from Melanocyte to Keratinocyte.

Glycolic acid
The molecule is the smallest in AHA. Penetration to skin is the fastest and removes Keratynocyte
effectively. Makes smooth and radiant skin.

Lavender Oil
Natural preservative and anti-inflammation effect scientifically proved. Calming down skin and makes
peaceful emotion.
BRPHARM PDT Gel

PDT Gel

1. Photodynamic Therapy is not possible even one is

lack among Photosensitizer, Light, Oxygen.
BRPHARM PDT Gel

PDT Gel TREATMENT

11 Preparation

STEP 1. Cleansing
- Washing or cleansing before PDT GEL treatment.
(Removal wastes in pores to enhance the absorption rate)

12 Extract acne

STEP 2. Extract acne and sebum

- If acne is big, slightly open pores of lesion with needle.

13 Open product

STEP 3. Preparation before applying PDT gel.

- 1~2 vials applies by the condition of skin.
① Open the Aluminum cap of vial Vial.
② Cover vial with conical cap included in box.
③ Ready to apply PDT Gel to skin.
BRPHARM PDT Gel

PDT Gel TREATMENT

14 Apply PDT Gel

STEP 4. Apply PDT Gel

- Apply PDT gel on acne lesion with brush or gloves hands
carefully avoiding around mouth and eyes

15 Incubation STEP 5. Incubation for 20 min. after applying PDT Gel [Close therapy]
- Block light 1
① Wrap on the applying area .
② Block light of wrapping area with towel.
- Block light 2
① Turn off the light for 20 min. if independent room. (No use of towel)

16 Shoot LED or IPL energy

STEP 6. Activate PDT Gel with LED or IPL ight
- Activates solution with certain wavelenght of LED or IPL .
① Shoot blue light LED for 20 min. (Don’t wipe solution on skin)
② Shoot with IPL (detailed in next page)
BRPHARM PDT Gel

PDT Gel TREATMENT

THE COMBINATION OF IPL & PDT TREATMENT PROCEDURE

※ Preparation : Remove PDT Gel from the Incubation treatment using facial sponges then apply IPL Gel.

· Start Treatment
Check that the hand piece with 430nm to 560nm filter is in operation.
Recommended 430nm.

· Pulse
Use single pulse mode rather than multi-pulse mode.

· Joule
Start energy level: 8 to 10 Joules.
For best results, aim to achieve an end point of slightly pink skin.

· Ask client for feedback about the treatment sensation.

Decrease joules for the hot sensation, and increase joules for the
tingling sensation.

· To prevent PIH from IPL, ice the treated area section by section
immediately after treatment.

· Blue light is safe and causes no-burn

BRPHARM PDT Gel

PDT Gel TREATMENT

8 Post Care

STEP 8. Stabilization
-Stabilize treated area with cold pack or calming pack.

19 Post Care

STEP 9. Completion
- Explain cautions in completion of treatment.
(Apply sun block carefully)

1 Treatment session and amount

Suggest once a week, total 4 times and can be adjusted by the condition of
patients.
I vial for 1 treatment and maximum 2 vials for the severe troubles.
BRPHARM PDT Gel

DIFFERENCES
BETWEEN BR PDT & EXISTING PDT
BRPHARM PDT Gel

PDT Gel MECHANISM OF ACTION

1. PDT GEL application Except eye and mouth area.

2. Active radical polymers formed react with water molecules and generate ROS -> result in decreased propionibacterium acnes and sebum secretion.

3. By-products created by activating tryptophan are swiftly excreted from the body in forms of amino acids through skin metabolism.

※ PDT is a new concept in the treatment of acne that is safe and efficient without side effects of photosensitivity.
BRPHARM PDT Gel

EXISTING PDT ALA MECHANISM OF ACTION

Protein oxidation
Lipid and fatty acid oxidation
mtDNA, nDNA damage
Steathepatitis

· 5-ALA is absorbed and reacts into the skin and synthesizes PPIX (protoporphyrin IX).

· Blue Light produces reactive oxygen species by PPIX and it influences both propionibacterium acnes and normal cells.

· ALA is the components of chlorophyll that is not decomposed, and

therefore excretion process is slow as it lacks in enzymes to dissolve proteins in the body.

· Remaining chlorophyll generate light-sensitive reactions resulting in flushing, production of dead skin cells and tanning.
BRPHARM PDT Gel

A NEW PHOTOSENSITIZER
FOR SAFE & FAST TREATMENT – PDT GEL

※ ADVANTAGE OF BRPHARM PDT TREATMENT

1. EFFECTIVENESS OF ABSORPTION MECHANISM.

 Maximizing the delivery of fat-soluble(oleophilic) form to sebaceous gland.

 Shorten Incubation time : total 20 minutes – a shorter overall treatment time by 50 percents.
total treatment time : 60 to 70 minutes.
 Available to omit MTS (saving costs)

2. THE BEST RESULTS WITH THE POWERFUL BACTERICIDAL EFFECT.

 POS of the powerful bactericidal effect : it is excellent about seborrheic dermatitis, anaerobic bacteria
like propionibacterium acnes and Staphylococcus.

3. WHITENING EFFECT, IMPROVING POST-BREAKOUT RED MARKS & UNEVEN SKIN TONE.

4. AVAILABLE OUTDOOR ACTIVITIES, MAKE-UP AND CLEANSING AFTER TREATMENT.

BRPHARM PDT Gel

※ BRPHARM PDT TREATMENT SAFETY

1. ECO- FRIENDLY INGREDIENTS.

 Fat-soluble amino acids is a patented ingredient and it is safe to use on humans.

2. SAFE TRYPTOPHAN COMPOUND ACTIONS.

 Bactericidal process of ROS after absorption through the skin and no need to wait metabolism
in propionibacterium acnes.

 Powerful bactericidal action - destroying lipid membrane of propionibacterium acnes except skin cells.

3. EMISSION OF PHOTOSENSITIZER.

 By-products created by activating tryptophan from photodegradation are swiftly excreted

from the body in forms of amino acids through skin metabolism.

 No remaining chlorophyll that generates light-sensitive reactions, without causing skin redness,
production of dead skin cells and tanning.

4. SAFE TREATMENT AND NO NEED TO TAKE ANY KIND OF DRUG LIKE STEROIDS.

 Available on teenage and do not use when pregnant or whilst breast feeding.
BRPHARM PDT Gel

RESULTS OF SELF-QUESTIONNAIRES FOR EFFICACY OF

BRPHARM PDT GEL

· The test results between BRPHARM PDT GEL

BRPHARM PDT GEL(Tryptophan Gel) and existing PDT ( ALA Gel)
· BRPHARM is more better than existing PDT.
The chart is shown that the remarkable improvements are reduction of sebum, novel acne and scaling.
BRPHARM PDT Gel

BRPHARM PDT Subject to Treatment

Purulent acne Seborrheic acne Inflammatory acne bane(acne in back)

Comedonic acne Chest acne Acne hard treat by existing antibiotic resistance or side effect of medicine

The best results with the powerful bactericidal effect destroying propionibacterium acnes.
Improvement of Acne
Great effect on seborrheic dermatitis.

Whitening Double benefits of PDT treatment treating post-breakout red marks , skin redness and PIH.

Reducing Reducing the size of sebaceous glands can result in controlling of sebum secretion
the production of sebum and inhibition of Propionibacterium acnes.

Comedones / Pore Controlling over the sebaceous glands, limiting sebum production and reducing pores
size.
BRPHARM PDT Gel

Compare other products

ALA PDT Tryptophan PDT Gel Benefits

[BRPHAM PDT Gel]
Symptoms Acne Acne Same as shown
Folliculitis (skin pore infection) Folliculitis
Rosacea (red nose) Rosacea
Seborrhea (sebum secretion) Seborrhea
Pregnant related Pregnant related patients
patients with pimples with pimples

Time Length 1-2 hours 20 mins. Shortened time span

(Incubation Time) of treatment

Effects of Treatment ALA needs lowering its curative ingredients to reduce the side effects , resulting in
diminishing the efficiency of the gel
Atfer Treatment Melanogenesis (melanin formaion) The equal side effect
( side effect ) (Hyperpigmentation) from the ray
Epidermal exfoliation
(Keratin drops)
Dry skin Erythema
Erythema (redness) Swelling
Swelling Pain
Pain Reactive acne
Reactive acne
BRPHARM PDT Gel

Cautions after BRPHARM PDT treatment

Simple washing face and simple make-up is possible on the treatment day.

Simple washing is recommended on the treatment day.

Exercise which can cause heat is not recommended for 2~3 days after
treatment.
Sunblock should be applied carefully on the treatment area.
BRPHARM PDT Gel

BRPHARM PDT Gel TREATMENT

RESULTS
BEFORE&AFTER
Actual clinical data from our doctors.
BRPHARM PDT Gel

Miss. 21 years
PDT Gel treatment 8 times procedure

BEFORE AFTER
BRPHARM PDT Gel

Miss. 21 years
PDT Gel treatment 8 times procedure
BRPHARM PDT Gel

Miss. 21 years
PDT Gel treatment 8 times procedure
BRPHARM PDT Gel

Miss. 26 years
PDT Gel treatment 4 times procedure

BEFORE AFTER
BRPHARM PDT Gel

Mr. 23 years
PDT Gel treatment 5 times procedure

BEFORE AFTER
BRPHARM PDT Gel

Mr. 23 years
PDT Gel treatment 5 times procedure

BEFORE AFTER
BRPHARM PDT Gel

Mr. 28 years
PDT Gel treatment 4 times procedure

BEFORE AFTER
BRPHARM PDT Gel

Miss. 30 years
PDT Gel treatment 4 times procedure

BEFORE AFTER
BRPHARM PDT Gel

Miss. 26 years
PDT Gel treatment 4 times procedure
BRPHARM PDT Gel

Miss. 26 years
PDT Gel treatment 7 times procedure