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Biological effects.
The individual PG (PGE, PGF, PGI = prostacyclin) possess different
biological effects.
1) Nociceptors.
PG increase sensitivity of sensory nerve fibers towards ordinarypain
stimuli (p. 194), i.e., at a given stimulus strength there is an increased
rate of evoked action potentials.
2)Thermoregulation.
PG raise the set point of hypothalamic (preoptic) thermoregulatory
neurons; body temperature increases (fever).
4)Gastric secretion.
PG promote the production of gastric mucus and reduce the formation
of gastric acid.
5) Menstruation.
PGF2α is believed to be responsible for the ischemic necrosis of
the endometrium preceding menstruation. The relative proportions of
individual PG are said to be altered in dysmenorrhea and excessive
menstrual
bleeding.
6)Uterine muscle.
PG stimulate labor contractions.
7)Bronchial muscle.
PGE2 and PGI2 induce bronchodilation; PGF2α causes constriction.