• Penyakit kardiovaskuler merupakan penyebab kematian terbesar diseluruh dunia • Penyakit jantung koroner masih menjadi penyebab kematian tertinggi • Berbagai upaya telah dilakukan untuk menurunkan inseden PJK • Marine omega-3 fatty acids have an important role in reducing coronary artery disease (CAD) risk
• This has been established by both
epidemiologic and randomized intervention trials. • Omega 3 (EPA dan DHA) paling bermanfaat untuk penyakit kardiovaskuler (membantu mencegah penyakit jantung koroner dan menghambat progresivitas pjk)
• Sumber biota laut disebut omega 3 laut
Rekomendasi American Heart Association (AHA) Mechanisms of CAD Protection Antiarrhythmic Effects and Prevention of Sudden Cardiac Death
• can reduce the risk for ventricular fibrillation and
subsequent sudden cardiac death • Omega-3 fatty acids are incorporated into myocardial cell membranes where they are a potent inhibitor of voltage-gated Na+/H+ channels in cardiac cardiomyocytes, preventing calcium overload by maintaining L-type calcium channels during periods of ischemic stress increases the ventricular refractory period and the electrical threshold required to induce an action potential-depolarization Triglyceride Lowering MOLECULAR BIOLOGY PATHWAY Thrombosis and Inflammation
• EPA can reduce CAD risk by effecting
processes that reduce both thrombosis and inflammation • As dietary EPA becomes incorporated into tissue membranes, it becomes a substitute • for arachidonic acid (AA), an omega-6 fatty acid that is 20 carbons in length • AA thromboxane A2 promotes platelet aggregation and vasoconstriction
• Conversely, EPA prostaglandin derivatives are of the A
3-series (ie, thromboxane A3), which are less vasoconstrictive and produce less platelet aggregation
• Likewise, the series of 5 lipoxygenase metabolites (ie,
leukotrienes) derived from EPA have a lower atherogenic potential than those derived from AA precursors because they have lesser proinflammatory effects. • Marine n-3 fatty acids also decrease chemoattractant , growth factor and adhesion molecule production and so could down-regulate processes leading to leukocyte and smooth muscle migration into the vessel wall intima. Blood Pressure Lowering • This effect is likely the result of increased systemic arterial compliance and improved endothelial function Stability of atherosclerotic plaques Terima kasih