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Objectives
■ Provide the definition and names for APRV
■ Explain the four set parameters.
■ Identify recruitment in APRV using exhaled
CO2.
■ Recommend appropriate initial settings for
APRV
■ Make adjustments based on arterial blood
gas results
■ Discontinue ventilation with APRV
Introduction
■ Airway pressure release ventilation (APRV) is a
relatively new mode of ventilatory support that,
although outlined in 1987, did not become available
in the United States until the mid-1990s.
■ APRV augments alveolar ventilation. Airway pressure
is released from an elevated baseline pressure to
produce an expiration. The elevated pressure
facilitates oxygenation, while the pressure release
increases minute ventilation.
Introduction
■ APRV has been successfully used in neonatal,
pediatric, and adult forms of respiratory failure.
Experimental and clinical use of APRV has been shown
to facilitate spontaneous breathing and is associated
with decreased peak airway pressures and improved
oxygenation/ventilation when compared with
conventional ventilation. Additionally, improvements in
hemodynamic parameters, splanchnic perfusion, and
reduced sedation/neuromuscular blocker requirements
have been reported.
Introduction
■ APRV may offer potential clinical advantages for
ventilator management of acute lung injury/acute
respiratory distress syndrome and may be
considered as an alternative “open lung approach” to
mechanical ventilation. Whether APRV reduces
mortality or increases ventilator-free days compared
with a conventional volume-cycled “lung protective”
strategy will require future randomized, controlled
trials
■ http://www.youtube.com/watch?v=BIT2Gy9nxp4
APRV Description
■ A mode of ventilation along with
spontaneous ventilation to promote lung
recruitment of collapsed and poorly
ventilated alveoli.
■ The CPAP is released periodically for a brief
period.
■ The short release along with spontaneous
breathing promote CO2 elimination.
■ Release time is short to prevent the peak
expiratory flow from returning to a zero
baseline.
APRV
APRV (Airway Pressure
Release Ventilation)
■ Provides two levels of CPAP and allows spontaneous breathing at
both levels when spontaneous effort is present
■ Both pressure levels are time triggered and time cycled
AKA
■ BiVent – Servo
■ APRV – Drager
■ BiLevel – Puritan Bennett
■ APRV – Hamilton
■ Etc.
Lung Protective Strategies
PB 840 BiLEVEL
T-High
The upper inflection point indicates a decrease in lung compliance and may specify
over-distention of the lung units.
The assessment of the static P/V curve can provide insight on how well a patient
will respond to the application of Airway Pressure Release Ventilation. Evaluation of
the “hysteresis” (difference between the inflation and the deflation limb) can
indicate the extent of potential lung units that may be recruited. If the patient has
very little probability for alveolar recruitment then APRV is less likely to be beneficial
and unjustified.
APRV: Setting P-High based on the Static
Pressure Volume Curve
If the patient meets indications for utilizing APRV, the operator can use
points on the P/V to safely set P-High.
P-High should be set always below the pressure which generated the “Upper
Inflection Point”.
P-High can be set 1-to-2 cmH2o above the “Lower Inflection Point”.
The practitioner can calculate “Best Compliance” and set P-High according to
the pressure that generated the best compliance (some P/V tools
automatically calculate this).
The static P/V curve provides a more diagnostic and patient tailored
approach to setting P-High.
P/V Tool for more intelligent patient assessment
The automated P/V Tool uses an empirical and repeatable method to find best
PEEP, based on respiratory mechanics.
It also enables sophisticated lung recruitment maneuvers and therapy
assessment.
This maneuver records the static pressure/volume curve quickly and easily at
the bedside. It employs an adjustable pressure ramp, in which airway pressure
is slowly increased to an upper limit as resultant volume and pressure are
recorded.
After the maneuver, the cursor function lets you inspect inflection points so that
you can easily visualize the linear portion of the compliance curve.
Advantages of APRV
■ Uses lower PIP to maintain oxygenation
and ventilation without compromising the
patient’s hemodynamics (Syndow AJRCCM 1994, Kaplan,
CC, 2001)
FLOW
Setting PEEP or Plow in APRV
■ http://www.youtube.com/watch?v=yW
-S2ZGLRqs&feature=related
Waveform Review
Airway Pressure Release Ventilation (APRV) showing the characteristic long
inspiratory time (TIMEH) (A) and short "release" time (TIMEL) (B). Note that
all spontaneous breathing occurs at PEEPH. [Note: Our module on APRV
applies generally to all variations popularly used].
Bi-Vent Settings
T PEEP T High
Spontaneous Breathing
Patient Trigger
(On P High)
Spontaneous Breathing w/PS
■ Decrease T High.
– Shorter T High means more release/min.
– No shorter than 3 seconds
– Example: T High 5 sec. = 12 releases/min
– T High 4 sec = 15 releases/min
■ Increase P High to increase DP and volume
exchange. (2-3 cm H2O/change)
– Monitor Vt
– PIP (best below 30 cm H2O)
■ Check T low. If possible increase T low to allow
more time for “exhalation.”
To Increase PaCO2
Paw PEEPL
cmH20
1 2 3 4 5 6 7
-20
Weaning Bi-Vent
Lower Rate
Longer T High
Add PS
Lower P High
Weaning Bi-Vent
Lower Rate
Longer T High
Add PS
Lower P High
Perceived Disadvantages
of APRV
APRV is a pressure-targeted mode of
ventilation.
Volume delivery depends on lung
compliance, airway resistance and the
patient’s spontaneous effort.
APRV does not completely support CO2
elimination, but relies on spontaneous
breathing
Disadvantages of APRV
■ With increased Raw (e.g.COPD)
– the ability to eliminate CO2 may be more difficult
– Due to limited emptying of the lung and short
release periods.
■ If spontaneous efforts are not matched during
the transition from Phigh to Plow and Plow to
Phigh, may lead to increased work load and
discomfort for the patient.
■ Limited staff experience with this mode may
make implementation of its use difficult.
The End