Escolar Documentos
Profissional Documentos
Cultura Documentos
Cyclins and
CDKs:
http://highered.m
heducation.com/
sites/983409233
9/student_view0/
chapter10/stimul
ation_of_cell_rep
lication.html
The temporal expression pattern of activities of the
cyclin–CDKs in mammalian cells.
Retinoblastoma (RB) controls the
initiation of DNA synthesis
RB halts cells at
G1 restriction
point by binding
(and inactivating)
the transcription
factor E2F
If the cycling cell is growing
properly, cyclin-CDK complexes
inactivate RB by phosphorylation
http://highered.mheducation.com/sites/9834092339/student_view0/chapter10/h
ow_tumor_suppressor_genes_block_cell_division.html
Retinoblastoma: Insights and solutions
Retinoblastoma: Insights and solutions
In apotosis, a cascade of
proteases called
caspases are initiated
that culminates in cell
suicide
Centrosome
Duplication &
Spindle
Checkpoint
Monitors assembly of
the spindle and its
attachment to
kinetochores during
mitosis in the interest
of maintaining normal
complement of
chromosomes
Cancer: some facts
1. Cancer cells have a small
number of mutations that
prevent normal checkpoint
function
2. Cancer is not one disease
but rather many diseases
with similar cellular
attributes
3. All cancer cells show
uncontrolled growth as a
result of mutations in a
relatively small number of
genes
4. Cancer is a disease of
somatic cells Capabilities acquired by cancer
cells
Cancer